ArticleItalian journal of pediatrics2022
The effects of the covid-19 pandemic on puberty: a cross-sectional, multicenter study from Turkey.
Article in Italian journal of pediatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Comparison of central precocious puberty frequency before and during COVID-19: a systematic review and meta-analysis.BMC endocrine disorders · 2024Pooled it
- Effect of dietary with Zhibai dihuang pills and gonadotropin-releasing-hormone-analogue on girls with precocious and rapidly progressive puberty.World journal of clinical cases · 2024Trial
- Central precocious puberty in Türkiye, 2018-2024: national incidence, prevalence, and changes across the COVID-19 period.Frontiers in endocrinology · 2026Article
- Trends in central precocious puberty incidence in Japan during the COVID-19 pandemic.Frontiers in pediatrics · 2026Article
- Automatic Bone Age Determination in Adult Height Prediction for Girls with Early Variants Puberty and Precocious PubertyJournal of clinical research in pediatric endocrinology · 2025Article
- Impact of the COVID-19 pandemic on the incidence of central precocious puberty: A PRISMA-ScR-COMPLIANT scoping review.Archives of endocrinology and metabolism · 2025Article
- Back to normal? A retrospective study on stimulation test and endocrinological diagnosis before, during and after COVID-19 pandemics.Frontiers in endocrinology · 2025Article
- Precocious puberty, pandemic and beyond.Pituitary · 2024Review
- Article
- Central Precocious Puberty During the COVID-19 Pandemic Period: A Systematic Review of Literature.Cureus · 2024Review
- Navigating Pubertal Goldilocks: The Optimal Pace for Hierarchical Brain Organization.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Early Normal Puberty and Accelerated Puberty in Girls: How Can We Avoid Unnecessary Treatment and Identify Children Who Are Likely to Benefit from Gonadotropin-Releasing Hormone Agonist Treatment?Turkish archives of pediatrics · 2023Article
- Year 2022: exploring COVID-19 pandemic in children.Italian journal of pediatrics · 2023Review
- Endocrinological Involvement in Children and Adolescents Affected by COVID-19: A Narrative Review.Journal of clinical medicine · 2023Review
- Decline in the Age of Menarche in Istanbul Schoolgirls Over the Last 12 YearsJournal of clinical research in pediatric endocrinology · 2023Article
- Pandemic and precocious puberty - a Google trends study.World journal of methodology · 2023Article
- Precocious puberty under stressful conditions: new understanding and insights from the lessons learnt from international adoptions and the COVID-19 pandemic.Frontiers in endocrinology · 2023Review
- COVID-19 pandemic phases and female precocious puberty: The experience of the past 4 years (2019 through 2022) in an Italian tertiary center.Frontiers in endocrinology · 2023Article
- Is blue light exposure a cause of precocious puberty in male rats?Frontiers in endocrinology · 2023Article
- Early and precocious puberty during the COVID-19 pandemic.Frontiers in endocrinology · 2022Review
Corrections and comments
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Authors and funding
11 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundsDuring the Coronavirus-19 disease (Covid-19) pandemic it was observed that the number of girls presenting with early puberty had increased. The aim of this study was to carry out a retrospective evaluation of the characteristics of girls who had been referred for evaluation of precocious puberty in five different pediatric endocrinology units, before and during the pandemic.
methodsThe study participants comprised 359 girls who were assigned into 2 groups a pre-pandemic group (n:214) and a pandemic group (n:145). Those participants (n:99) who had medical records in the follow-up period were classified into 3 subgroups according to the time of presentation and follow-up visits (group-1: first admission and follow-up visit before the pandemic, group-2: first admission before the pandemic, the follow-up visit during the pandemic, group-3: first admission and follow-up visit during the pandemic).
resultsThe age at presentation and age at pubertal onset were both significantly lower in the pandemic group than those in the pre-pandemic group(8.1 vs 8.6, p: < 0.001,7.7 vs 7.9,p:0.013, respectively). There was no significant difference between the body mass index standard deviation scores (BMI-SDS) values of the groups (0.57 vs 0.51, p:0.430). The initiation rate of pubertal suppression therapy at the time of presentation was significantly higher in the pandemic group compared to that of the pre-pandemic group (7.7%vs 27.5%), and in groups-2 & 3 compared to group-1, during follow-up (20%&44%vs 8%).
conclusionOur research showed that the onset of puberty occurred earlier in the pandemic period compared to the previous year, and the need for pubertal suppression therapy increased during the pandemic.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.