Evidence map›Paper›PMID 35963953›Full record

ArticleCellular and molecular life sciences : CMLS2022

Two major genes associated with autoimmune arthritis, Ncf1 and Fcgr2b, additively protect mice by strengthening T cell tolerance.

Qijing Li, Jianghong Zhong, Huqiao Luo, Vilma Urbonaviciute, Zhongwei Xu, Chang He, Rikard Holmdahl

Open access · hybridAbstract read
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Qijing LiThe Second Affiliated Hospital of Xi'an Jiaotong University (Xibei Hospital), Xi'an, China.
Jianghong ZhongMedical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden.
Huqiao LuoMedical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden.
Vilma UrbonaviciuteMedical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden.
Zhongwei XuMedical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden.
Chang HeMedical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden.
Rikard HolmdahlThe Second Affiliated Hospital of Xi'an Jiaotong University (Xibei Hospital), Xi'an, China. rikard.holmdahl@ki.se.
Karolinska Institutet · SEFirst Affiliated Hospital of Xi'an Jiaotong University · CN

Funding

Beihang University KG16080401Innovation Capacity Support Plan of Shaanxi Province 2020GHJD-06Innovation Capacity Support Plan of Shaanxi Province S2020-ZC-GHJD-0012Knut och Alice Wallenbergs Stiftelse KAW 2015.0063National Natural Science Foundation of China 32070913Swedish Cancer Foundation 190341Pj01H
6 · The paper itself

Abstract

A breach of T cell tolerance is considered as a major step in the pathogenesis of rheumatoid arthritis. In collagen-induced arthritis (CIA) model, immunization with type II collagen (COL2) leads to arthritis in mice through T cells responding to the immunodominant COL2

Indexed as

Arthritis, ExperimentalAutoimmune DiseasesAnimalsCollagen Type IIHumansImmune ToleranceMiceNADPH OxidasesReceptors, IgGT-LymphocytesCollagen Type IIFCGR2B protein, humanFcgr2b protein, mouseNADPH Oxidasesneutrophil cytosolic factor 1Receptors, IgGFc receptorImmune regulationNOX2p47phoxRheumatoid arthritisType II collagen

Identifiers

PMID35963953
PMCPMC9375767
OpenAlexW4291363070

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.