ArticleNature communications2022
A mid-infrared lab-on-a-chip for dynamic reaction monitoring.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Phase-Controlled Asymmetric Resonances for Enhanced Spectral Slope in a Ge-OI Microring Resonator at 4.2 μm.Nanophotonics (Berlin, Germany) · 2026Article
- In-sensor multispectral perception for near- and mid-infrared discrimination.Nature communications · 2026Article
- Plasmonic-enhanced lanthanide nanotransducers for mid-infrared detection.Nature communications · 2026Article
- Infrared Near-Field Microscopy as a Platform for Nanoscale Biomedical Spectroscopy and Imaging.ACS applied materials & interfaces · 2026Review
- Broadband comb spectroscopy through spectral envelope shaping.Nature communications · 2026Article
- Quantum walk comb in a dual waveguide quantum cascade laser.Nature communications · 2025Article
- Micro-mirror aided mid-infrared plasmonic beam combiner monolithically integrated with quantum cascade lasers and detectors.Nanophotonics (Berlin, Germany) · 2025Article
- Biofunctionalization of chalcogenide glass fiber to enhance real time and label free detection by mid infrared spectroscopy.Scientific reports · 2025Article
- Bio-inspired mid-infrared neuromorphic transistors for dynamic trajectory perception using PdSeNature communications · 2025Article
- Integrated Optics Waveguides and Mesoporous Oxides for the Monitoring of Volatile Organic Compound Traces in the Mid-Infrared.Applied spectroscopy · 2025Article
- Electric-Field Molecular Fingerprinting to Probe Cancer.ACS central science · 2025Article
- Advances in MEMS, Optical MEMS, and Nanophotonics Technologies for Volatile Organic Compound Detection and Applications.Small science · 2025Review
- On-Chip Metamaterial-Enhanced Mid-Infrared Photodetectors with Built-In Encryption Features.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Mid-Infrared Photonic Sensors: Exploring Fundamentals, Advanced Materials, and Cutting-Edge Applications.Sensors (Basel, Switzerland) · 2025Review
- Unipolar quantum optoelectronics for high speed direct modulation and transmission in 8-14 µm atmospheric window.Nature communications · 2024Article
- Mid-infrared Ring Interband Cascade Laser: Operation at the Standard Quantum Limit.ACS photonics · 2024Article
- A Portable Infrared Attenuated Total Reflection Spectrometer for Food Analysis.Applied spectroscopy · 2023Article
- Research Progress in Surface-Enhanced Infrared Absorption Spectroscopy: From Performance Optimization, Sensing Applications, to System Integration.Nanomaterials (Basel, Switzerland) · 2023Review
- Artificial intelligence-coupled plasmonic infrared sensor for detection of structural protein biomarkers in neurodegenerative diseases.Science advances · 2023Article
- Expanding chiral metamaterials for retrieving fingerprints via vibrational circular dichroism.Light, science & applications · 2023Article
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mid-infrared spectroscopy is a sensitive and selective technique for probing molecules in the gas or liquid phase. Investigating chemical reactions in bio-medical applications such as drug production is recently gaining particular interest. However, monitoring dynamic processes in liquids is commonly limited to bulky systems and thus requires time-consuming offline analytics. In this work, we show a next-generation, fully-integrated and robust chip-scale sensor for online measurements of molecule dynamics in a liquid solution. Our fingertip-sized device utilizes quantum cascade technology, combining the emitter, sensing section and detector on a single chip. This enables real-time measurements probing only microliter amounts of analyte in an in situ configuration. We demonstrate time-resolved device operation by analyzing temperature-induced conformational changes of the model protein bovine serum albumin in heavy water. Quantitative measurements reveal excellent performance characteristics in terms of sensor linearity, wide coverage of concentrations, extending from 0.075 mg ml
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.