Evidence map›Paper›PMID 35963484›Full record

ArticleFitoterapia2022

Cytotoxic constituents of Glycosmis ovoidea collected in Vietnam.

Peter J Blanco Carcache, Gerardo D Anaya Eugenio, Tran Ngoc Ninh, Curtis E Moore, José Rivera-Chávez, Yulin Ren, Djaja D Soejarto, A Douglas Kinghorn

Abstract read
In one paragraph

Article in Fitoterapia, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Peter J Blanco CarcacheDivision of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH 43210, United States.
Gerardo D Anaya EugenioDivision of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH 43210, United States.
Tran Ngoc NinhInstitute of Ecology and Biological Resources, Vietnam Academy of Science and Technology, Hoang Quoc Viet, Cau Giay, Hanoi, Viet Nam.
Curtis E MooreDepartment of Chemistry and Biochemistry, College of Arts and Sciences, The Ohio State University, Columbus, OH 43210, United States.
José Rivera-ChávezDepartamento de Productos Naturales, Instituto de Química, UNAM, Cuidad de México 04510, Mexico.
Yulin RenDivision of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH 43210, United States.
Djaja D SoejartoDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, United States; Science and Education, Field Museum of Natural History, Chicago, IL 60605, United States.
A Douglas KinghornDivision of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH 43210, United States. Electronic address: kinghorn.4@osu.edu.

Funding

Project 3:Isolation Chemistry of Filamentous Fungi and Biological EvaluationP01CA125066 · NCI · OHIO STATE UNIVERSITY · PI JAMES R FUCHS · 2007 to 2026
$27.2M
NCI NIH HHS P01 CA125066
6 · The paper itself

Abstract

Compounds derived from natural sources have been major contributors to the area of cancer chemotherapy for decades. As part of an ongoing effort to discover anticancer drug leads from tropical plants, a large-scale collection of Glycosmis ovoidea Pierre (Rutaceae), was made at Nui Chua National Park, Vietnam. Activity-guided fractionation of the chloroform-soluble fractions led to the isolation of nine coumarins, including the new compound, 1-(7-methoxy-2-oxo-2H-chromen-8-yl)-3-methyl-1-oxobut-2-en-2-yl (S)-2-methylbutanoate (1). An close analogue of 1, namely, kincuongin (2), was deemed as non-cytotoxic (IC

Indexed as

Antineoplastic AgentsFlavonesRutaceaeAnimalsCell Line, TumorChloroformCoumarinsMolecular StructureNF-kappa BPoly(ADP-ribose) Polymerase InhibitorsVietnamZebrafishAntineoplastic AgentsChloroformCoumarinsFlavonesNF-kappa BPoly(ADP-ribose) Polymerase InhibitorsCoumarinsCytotoxic activityFlavoneGlycosmis ovoideaMolecular dockingNF-κBPARP-1RutaceaeWest blotZebrafish model toxicity evaluation

Identifiers

PMID35963484
PMCPMC9532375

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.