ReviewProgress in neurobiology2022
Adolescent sleep and the foundations of prefrontal cortical development and dysfunction.
Review in Progress in neurobiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 4 syntheses or guidelines pooled it, 61 citations in OpenAlex.
- Pooled it
- Effects of exercise interventions on sleep quality in adolescents: a systematic review and meta-analysis.Frontiers in public health · 2025Pooled it
- Effects of acupuncture on the brain in primary insomnia: a coordinate-based meta-analysis of fMRI studies.Frontiers in neurology · 2023Pooled it
- Sleep patterns of Canadian women across the life course: A systematic review.Women's health (London, England)Pooled it
- Treating preschooler behavioural sleep problems via parent-mediated telehealth: A randomized controlled trial.The British journal of clinical psychology · 2026Trial
- A one-hour delayed school start improves sleep, sleepiness and inhibitory control in early adolescents in a randomized controlled trial.Scientific reports · 2026Trial
- The effects of transcranial magnetic stimulation on state and trait anxiety among undergraduates with insomnia symptoms: a randomized control trial.BMC psychology · 2026Trial
- Multivariate associations between sleep patterns and self-regulation in adolescence: Canonical correlation analysis across ABCD and NCANDA cohorts.Chronobiology international · 2026Article
- Atopic dermatitis and attention-deficit/hyperactivity disorder comorbidity in children and adolescents: Epidemiology, mechanisms, and clinical management.Pediatric investigation · 2026Review
- Effects of insomnia-focused psychological and behavioral interventions on depressive symptoms in children and adolescents: a systematic review and meta-analysis.European child & adolescent psychiatry · 2026Review
- Region- and Layer-Specific Glutamatergic Synapse Development in the Nascent Cortical Hierarchy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Public involvement and co-design of longitudinal studies of sleep health alongside young people with rare genetic conditions.Research involvement and engagement · 2026Article
- Structural Brain Correlates of Insufficient Sleep in Adolescents: A Narrative Review of MRI Evidence.Children (Basel, Switzerland) · 2026Review
- Sleep problems and emotional and behavioral problems among adolescents: examining independent types, cumulative scores, and latent patterns.Child and adolescent psychiatry and mental health · 2026Article
- Sleep deprivation and memory: A neurobiological perspective.IBRO neuroscience reports · 2026Article
- Prevalence of Sleep Deprivation and its Associations with Depressive Symptoms, Academic Performance, and Sleep Hygiene among School-going Adolescents (12-18 Years) in Urban Delhi.Indian journal of community medicine : official publication of Indian Association of Preventive & Social Medicine · 2026Article
- Association between weekend catch-up sleep and depressive symptoms in young adults: evidence from two national dataset.Scientific reports · 2026Article
- The relationship between sleep procrastination and depressive symptoms among adolescents in Urumqi: the mediating role of eating behavior.BMC psychology · 2026Article
- Linking Social Anxiety to Depressive Symptoms in Adolescents: The Dual Mediating Roles of Perceived Social Support and Sleep Quality.Actas espanolas de psiquiatria · 2026Observational
- Subtypes of adolescent major depressive disorder characterized by divergent information dynamics in sensory-association cortices.Nature communications · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Modern life poses many threats to good-quality sleep, challenging brain health across the lifespan. Curtailed or fragmented sleep may be particularly damaging during adolescence, when sleep disruption by delayed chronotypes and societal pressures coincides with our brains preparing for adult life via intense refinement of neural connectivity. These vulnerabilities converge on the prefrontal cortex, one of the last brain regions to mature and a central hub of the limbic-cortical circuits underpinning decision-making, reward processing, social interactions and emotion. Even subtle disruption of prefrontal cortical development during adolescence may therefore have enduring impact. In this review, we integrate synaptic and circuit mechanisms, glial biology, sleep neurophysiology and epidemiology, to frame a hypothesis highlighting the implications of adolescent sleep disruption for the neural circuitry of the prefrontal cortex. Convergent evidence underscores the importance of acknowledging, quantifying and optimizing adolescent sleep's contributions to normative brain development and to lifelong mental health.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.