Evidence map›Paper›PMID 35962942›Full record

ArticleJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine2023

Short-term positive effects of a mandibular advancement device in a selected phenotype of patients with moderate obstructive sleep apnea: a prospective study.

Bertien Buyse, Pham Anh Hong Nguyen, Joke Leemans, Veroniek Verhaeghe, Marleen Peters, Simon Strobbe, Isabelle Van Valckenborgh, Catharina Belge, Dries Testelmans

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In one paragraph

Article in Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Bertien BuyseDepartment of Pulmonology, Louvain University Center for Sleep and wake disorders (LUCS), University Hospital Gasthuisberg, Leuven, Belgium.
Pham Anh Hong NguyenDepartment of Pulmonology, Louvain University Center for Sleep and wake disorders (LUCS), University Hospital Gasthuisberg, Leuven, Belgium.
Joke LeemansDepartment of Pulmonology, Louvain University Center for Sleep and wake disorders (LUCS), University Hospital Gasthuisberg, Leuven, Belgium.
Veroniek VerhaegheDentistry Care, UZ Leuven, Leuven, Belgium.
Marleen PetersENT, Head and Neck Surgery, UZ Leuven, Leuven, Belgium.
Simon StrobbeENT, Head and Neck Surgery, UZ Leuven, Leuven, Belgium.
Isabelle Van ValckenborghENT, AZ Diest, Diest, Belgium.
Catharina BelgeDepartment of Pulmonology, Louvain University Center for Sleep and wake disorders (LUCS), University Hospital Gasthuisberg, Leuven, Belgium.
Dries TestelmansDepartment of Pulmonology, Louvain University Center for Sleep and wake disorders (LUCS), University Hospital Gasthuisberg, Leuven, Belgium.
KU Leuven · BEUniversitair Ziekenhuis Leuven · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

STUDY

objectivesTo evaluate (determinants of) treatment success of mandibular advancement device application in a selected phenotype of patients with obstructive sleep apnea (OSA).

methodsNinety nonobese patients with moderate OSA (obstructive apnea-hypopnea index [OAHI] ≥ 15 and < 30 events/h) without comorbidities were prospectively included. Polysomnography was performed at baseline and with a mandibular advancement device. A drug-induced sleep endoscopy with jaw thrust was performed in 83%.

resultsOAHI reduction ≥ 50% was observed in 73%, OAHI reduction ≥ 50% with OAHI < 10 events/h in 70%, and complete OSA resolution (OAHI < 5 events/h) in 40%. Patients with nonpositional OSA showed a significantly higher rate of complete OSA resolution: Posttest probability increased to 67%. In patients with total disappearance of collapse at velum level and at all levels during drug-induced sleep endoscopy with jaw thrust, the drop in OAHI was impressive with an infinitively high positive likelihood ratio. However, the proportion of patients having nonpositional OSA or the drug-induced sleep endoscopy characteristics as described above was < 20%. The change in snoring disturbance based on a visual analog scale was 76% (interquartile range 40-89%,

conclusionsIn this predefined OSA phenotype, a mandibular advancement device was effective in reduction of OAHI and in amelioration of symptoms. Stratification by nonpositional OSA and findings on drug-induced sleep endoscopy with jaw thrust increased treatment success defined as reduction in OAHI. However, the clinical relevance can be questioned because only a small number of patients demonstrated these characteristics. CITATION: Buyse B, Nguyen PAH, Leemans J, et al. Short-term positive effects of a mandibular advancement device in a selected phenotype of patients with moderate obstructive sleep apnea: a prospective study.

Indexed as

Mandibular AdvancementSleep Apnea, ObstructiveHumansOcclusal SplintsPhenotypePolysomnographyProspective StudiesTreatment Outcomedaytime sleepinessdrug-induced sleep endoscopymandibular advancementobstructive sleep apneapersonalized medicinepolysomnographysnoringsupine position

Identifiers

PMID35962942
PMCPMC9806777
OpenAlexW4291284856

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.