Evidence map›Paper›PMID 35962903›Full record

ArticleJournal of physiology and biochemistry2022

Trimethylamine N-oxide facilitates the progression of atrial fibrillation in rats with type 2 diabetes by aggravating cardiac inflammation and connexin remodeling.

Wan-Ying Jiang, Jun-Yu Huo, Sheng-Chan Wang, Yan-Di Cheng, Yi-Ting Lyu, Zhi-Xin Jiang, Qi-Jun Shan

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In one paragraph

Article in Journal of physiology and biochemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
3.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Wan-Ying Jiang *Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Jun-Yu Huo *Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Sheng-Chan WangDepartment of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Yan-Di ChengDepartment of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Yi-Ting LyuDepartment of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Zhi-Xin JiangDepartment of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Qi-Jun ShanDepartment of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China. qjshan@njmu.edu.cn.ORCID http://orcid.org/0000-0001-8783-8057
Jiangsu Province Hospital · CN

Funding

National Natural Science Foundation of China 81770333National Natural Science Foundation of China 81800350
6 · The paper itself

Abstract

Diabetes is an independent risk factor for atrial fibrillation (AF). This study aimed to elucidate the pathophysiology of diabetes-related AF from the perspective of the gut microbial metabolite trimethylamine N-oxide (TMAO). In the present study, male rats received either a normal diet to serve as the control group or a high-fat diet/streptozotocin to induce type 2 diabetes mellitus. Then, diabetic rats were divided into two groups based on the presence or absence of 3,3-dimethyl-1-butanol (DMB, a specific TMAO inhibitor) in drinking water: the diabetic cardiomyopathy (DCM) group and the DCM + DMB group. Eight weeks later, compared with control rats, rats in the DCM group exhibited gut microbiota dysbiosis and systemic TMAO elevation. The inflammatory cytokines IL-1β, IL-6, and TNF-α were markedly increased in the atria of rats in the DCM group. Downregulated expression of connexin 40 and lateralized distribution of connexin 43 were also observed in the atria of DCM rats. AF inducibility was significantly higher in DCM rats than in control rats. Furthermore, DMB treatment effectively ameliorated atrial inflammation and connexin remodeling while markedly reducing plasma TMAO levels. DMB treatment also decreased the vulnerability of diabetic rats to AF. In conclusion, TMAO might promote atrial inflammation and connexin remodeling in the development of diabetes, which may play a key role in mediating diabetes-related AF.

Indexed as

Atrial FibrillationAtrial RemodelingDiabetes Mellitus, ExperimentalDiabetes Mellitus, Type 2AnimalsConnexinsInflammationMaleMethylaminesRatsConnexinsMethylaminestrimethyloxamine3,3-Dimethyl-1-butanolAtrial fibrillationTrimethylamine N-oxideType 2 diabetes

Identifiers

PMID35962903
OpenAlexW4291115867

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.