Evidence map›Paper›PMID 35962888›Full record

SynthesisLa Radiologia medica2022

Accuracy of artificial intelligence for the detection of intracranial hemorrhage and chronic cerebral microbleeds: a systematic review and pooled analysis.

Stavros Matsoukas, Jacopo Scaggiante, Braxton R Schuldt, Colton J Smith, Susmita Chennareddy, Roshini Kalagara, Shahram Majidi, Joshua B Bederson, Johanna T Fifi, J Mocco and 1 more

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in La Radiologia medica, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 2 pooled it
6.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 54 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Stavros MatsoukasDepartment of Neurosurgery, Mount Sinai Health System, Annenberg Building, Room 20-86, 1468 Madison Ave, New York, NY, 10029, USA. Stavros.matsoukas@mountsinai.org.ORCID http://orcid.org/0000-0001-5902-0637
Jacopo ScaggianteDepartment of Neurosurgery, Mount Sinai Health System, Annenberg Building, Room 20-86, 1468 Madison Ave, New York, NY, 10029, USA.ORCID http://orcid.org/0000-0002-9531-9131
Braxton R SchuldtDepartment of Neurosurgery, Mount Sinai Health System, Annenberg Building, Room 20-86, 1468 Madison Ave, New York, NY, 10029, USA.ORCID http://orcid.org/0000-0002-1737-707X
Colton J SmithDepartment of Neurosurgery, Mount Sinai Health System, Annenberg Building, Room 20-86, 1468 Madison Ave, New York, NY, 10029, USA.ORCID http://orcid.org/0000-0001-8427-0056
Susmita ChennareddyDepartment of Neurosurgery, Mount Sinai Health System, Annenberg Building, Room 20-86, 1468 Madison Ave, New York, NY, 10029, USA.ORCID http://orcid.org/0000-0002-0503-6876
Roshini KalagaraDepartment of Neurosurgery, Mount Sinai Health System, Annenberg Building, Room 20-86, 1468 Madison Ave, New York, NY, 10029, USA.ORCID http://orcid.org/0000-0002-2607-0408
Shahram MajidiDepartment of Neurosurgery, Mount Sinai Health System, Annenberg Building, Room 20-86, 1468 Madison Ave, New York, NY, 10029, USA.ORCID http://orcid.org/0000-0003-2971-6216
Joshua B BedersonDepartment of Neurosurgery, Mount Sinai Health System, Annenberg Building, Room 20-86, 1468 Madison Ave, New York, NY, 10029, USA.
Johanna T FifiDepartment of Neurosurgery, Mount Sinai Health System, Annenberg Building, Room 20-86, 1468 Madison Ave, New York, NY, 10029, USA.ORCID http://orcid.org/0000-0001-7786-5668
J MoccoDepartment of Neurosurgery, Mount Sinai Health System, Annenberg Building, Room 20-86, 1468 Madison Ave, New York, NY, 10029, USA.
Christopher P KellnerDepartment of Neurosurgery, Mount Sinai Health System, Annenberg Building, Room 20-86, 1468 Madison Ave, New York, NY, 10029, USA.ORCID http://orcid.org/0000-0003-4604-8205
Mount Sinai Health System · US

Funding

Conduits: Mount Sinai Health System Translational Science HubUL1TR004419 · NCATS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Rosalind J Wright · 2022 to 2026
$46.4M
6 · The paper itself

Abstract

backgroundArtificial intelligence (AI)-driven software has been developed and become commercially available within the past few years for the detection of intracranial hemorrhage (ICH) and chronic cerebral microbleeds (CMBs). However, there is currently no systematic review that summarizes all of these tools or provides pooled estimates of their performance.

methodsIn this PROSPERO-registered, PRISMA compliant systematic review, we sought to compile and review all MEDLINE and EMBASE published studies that have developed and/or tested AI algorithms for ICH detection on non-contrast CT scans (NCCTs) or MRI scans and CMBs detection on MRI scans.

resultsIn total, 40 studies described AI algorithms for ICH detection in NCCTs/MRIs and 19 for CMBs detection in MRIs. The overall sensitivity, specificity, and accuracy were 92.06%, 93.54%, and 93.46%, respectively, for ICH detection and 91.6%, 93.9%, and 92.7% for CMBs detection. Some of the challenges encountered in the development of these algorithms include the laborious work of creating large, labeled and balanced datasets, the volumetric nature of the imaging examinations, the fine tuning of the algorithms, and the reduction in false positives.

conclusionsNumerous AI-driven software tools have been developed over the last decade. On average, they are characterized by high performance and expert-level accuracy for the diagnosis of ICH and CMBs. As a result, implementing these tools in clinical practice may improve workflow and act as a failsafe for the detection of such lesions. REGISTRATION-URL: https://www.crd.york.ac.uk/prospero/ Unique Identifier: CRD42021246848.

Indexed as

Artificial IntelligenceCerebral HemorrhageHumansIntracranial HemorrhagesMagnetic Resonance ImagingAI-assisted diagnosisArtificial intelligenceChronic microbleedsConvolutional neural networkIntracranial hemorrhageNon-contrast CT scan

Identifiers

PMID35962888
OpenAlexW4291196966

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.