Evidence map›Paper›PMID 35962456›Full record

ArticleJournal of animal science and biotechnology2022

Lactobacillus rhamnosus GG ameliorates DON-induced intestinal damage depending on the enrichment of beneficial bacteria in weaned piglets.

Yongsong Bai, Kaidi Ma, Jibo Li, Zhongshuai Ren, Jing Zhang, Anshan Shan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of animal science and biotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
9.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 64 citations in OpenAlex.

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  17. Gut microbiota and acne: A Mendelian randomization study.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Yongsong Bai *Institute of Animal Nutrition, Northeast Agricultural University, Harbin, 150030, P. R. China.
Kaidi Ma *Institute of Animal Nutrition, Northeast Agricultural University, Harbin, 150030, P. R. China.
Jibo LiInstitute of Animal Nutrition, Northeast Agricultural University, Harbin, 150030, P. R. China.
Zhongshuai RenCollege of Animal Sciences, Jilin University, Key Laboratory of Zoonosis Research, Ministry of Education, Changchun, 130062, P. R. China.
Jing ZhangCollege of Animal Sciences, Jilin University, Key Laboratory of Zoonosis Research, Ministry of Education, Changchun, 130062, P. R. China. zhang_jing99@jlu.edu.cn.
Anshan ShanInstitute of Animal Nutrition, Northeast Agricultural University, Harbin, 150030, P. R. China. asshan@neau.edu.cn.ORCID http://orcid.org/0000-0003-2830-7509
Northeast Agricultural University · CNJilin University · CN

Funding

National Natural Science Foundation of China U21A20251Natural Science Foundation of Heilongjiang Province TD2019C001State Key Program of National Natural Science Foundation of China 32030101
6 · The paper itself

Abstract

backgroundDeoxynivalenol (DON) is one of the most common environmental pollutants that induces intestinal inflammation and microbiota dysbiosis. Lactobacillus rhamnosus GG (LGG) is a probiotic that not only has anti-inflammatory effects, but also shows protective effect on the intestinal barrier. However, it is still unknown whether LGG exerts beneficial effects against DON-induced intestinal damage in piglets. In this work, a total of 36 weaned piglets were randomized to one of four treatment groups for 21 d. The treatment groups were CON (basal diet); LGG (basal diet supplemented with 1.77 × 10

resultSupplementation of LGG can enhance growth performance of piglets exposed to DON by improving intestinal barrier function. LGG has a mitigating effect on intestinal inflammation induced by DON exposure, largely through repression of the TLR4/NF-κB signaling pathway. Furthermore, supplementation of LGG increased the relative abundances of beneficial bacteria (e.g., Collinsella, Lactobacillus, Ruminococcus_torques_group and Anaerofustis), and decreased the relative abundances of harmful bacteria (e.g., Parabacteroides and Ruminiclostridium_6), and also promoted the production of SCFAs.

conclusionsLGG ameliorates DON-induced intestinal damage, which may provide theoretical support for the application of LGG to alleviate the adverse effects induced by DON exposure.

Indexed as

DeoxynivalenolGut microbiotaIntestinal inflammationLactobacillus rhamnosus GGPiglets

Identifiers

PMID35962456
PMCPMC9375241
OpenAlexW4290851667

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.