Evidence map›Paper›PMID 35962370›Full record

ArticleBMC infectious diseases2022

Antimicrobial resistance of Neisseria gonorrhoeae isolated from patients attending sexually transmitted infection clinics in Urban Hospitals, Lusaka, Zambia.

Kelvin L Sarenje, Owen Ngalamika, Margaret C Maimbolwa, Amon Siame, Sody M Munsaka, Geoffrey Kwenda

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC infectious diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Tetracycline-resistantJAC-antimicrobial resistance · 2025
    Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Kelvin L SarenjeDepartment of Biomedical Sciences, School of Health Sciences, University of Zambia, P.O. Box 50110, Lusaka, Zambia. kelvinsarenje@yahoo.com.
Owen NgalamikaDepartment of Dermato-Venereology, University Teaching Hospital, Lusaka, Zambia.
Margaret C MaimbolwaDepartment of Midwifery Child, and Women's Health, School of Nursing Sciences, University of Zambia, Lusaka, Zambia.
Amon SiameCentre for Infectious Disease Research, Lusaka, Zambia.
Sody M MunsakaDepartment of Biomedical Sciences, School of Health Sciences, University of Zambia, P.O. Box 50110, Lusaka, Zambia.
Geoffrey KwendaDepartment of Biomedical Sciences, School of Health Sciences, University of Zambia, P.O. Box 50110, Lusaka, Zambia.
University of Zambia · ZMCentre for Infectious Disease Research in Zambia · ZMUniversity Teaching Hospital · ZM

Funding

Zambia AIDS Malignancies Diagnosis and Pathogenesis Program SupplementU54CA221204 · NCI · UNIVERSITY OF NEBRASKA LINCOLN · PI WOOD, CHARLES · 2017 to 2022
$3.8M
AIDS Malignancies Training and Research International Program (AMTRIP)D43TW010354 · FIC · UNIVERSITY OF NEBRASKA LINCOLN · PI Chipepo Kankasa, Charles Wood · 2016 to 2026
$2.8M
FIC NIH HHS D43 TW010354NCI NIH HHS U54 CA221204
6 · The paper itself

Abstract

backgroundNeisseria gonorrhoeae, the causative agent for sexually transmitted infection (STI) gonorrhoea, has emerged with a significant public health impact on acquiring resistance to antimicrobials available for treatment. The resistance of N. gonorrhoeae limit treatment options and contributed to high morbidity associated with gonorrhoea. Data on antimicrobial resistance (AMR) profiles in N. gonorrhoeae is scares in Zambia. This study aimed to determine the antibiotic susceptibilities in N. gonorrhoeae isolates from Lusaka, Zambia.

methodsA prospective cross-sectional study was conducted on 630 STI patients who presented with urethral or vaginal discharge from 2019 to 2020. Urethral and endocervical secretions were cultured on Modified Thayer Martin agar and incubated at 36 °C ± 1 °C in 5% CO

resultsA total of 630 patients were recruited of which 46% (290/630) with the median of 29 years and interquartile range (IQR) of 19-39 years were male. The median of the females was 26 years and IQR of 15-37 years. Neisseria gonorrhoeae was isolated from 19.4% (122/630) patients of which 72.9% (89/122) were male, with highest prevalence of isolation in the age category of 25-34 years. The prevalence of resistance was high to penicillin (85.2%), tetracycline (68.9%) and ciprofloxacin (59.8%) with MIC

conclusionThe N. gonorrhoeae resistance to penicillin, tetracycline and ciprofloxacin was high necessitating revision of the treatment guidelines. However, no resistance to ceftriaxone was detected. Therefore, monitoring of antibiotic resistance remains critical in Zambia.

Indexed as

Anti-Infective AgentsGonorrheaAdultAnti-Bacterial AgentsCeftriaxoneCiprofloxacinCross-Sectional StudiesDrug Resistance, BacterialFemaleHospitals, UrbanHumansMaleMicrobial Sensitivity TestsNeisseria gonorrhoeaePenicillinsProspective StudiesAnti-Bacterial AgentsAnti-Infective AgentsCeftriaxoneCiprofloxacinPenicillinsTetracyclineAntimicrobial resistanceEpsilometer testNeisseria gonorrhoeaeZambia

Identifiers

PMID35962370
PMCPMC9373640
OpenAlexW4290851653

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.