Evidence map›Paper›PMID 35962259›Full record

ArticleActa diabetologica2022

Increased serum 12-hydroxyeicosatetraenoic acid levels are correlated with an increased risk of diabetic retinopathy in both children and adults with diabetes.

Shuli Chen, Yu Qian, Qiurong Lin, Zhangling Chen, Zhaoyu Xiang, Lipu Cui, Jiaqi Sun, Xinran Qin, Yi Xu, Lina Lu and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta diabetologica, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Morphological changes of β-Zone Peripapillary Atrophy (β-PPA) in children with type 1 Diabetes: A longitudinal study.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026
    Observational
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  9. PMToxics · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Shuli ChenDepartment of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University, School of Medicine, No.100 Haining Road, Shanghai, 200080, China.
Yu QianDepartment of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University, School of Medicine, No.100 Haining Road, Shanghai, 200080, China.
Qiurong LinShanghai Eye Disease Prevention and Treatment Center/Shanghai Eye Hospital, Shanghai, China.
Zhangling ChenDepartment of Ophthalmology, Shanghai General Hospital of Nanjing Medical University, Shanghai, China.
Zhaoyu XiangDepartment of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University, School of Medicine, No.100 Haining Road, Shanghai, 200080, China.
Lipu CuiDepartment of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University, School of Medicine, No.100 Haining Road, Shanghai, 200080, China.
Jiaqi SunDepartment of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University, School of Medicine, No.100 Haining Road, Shanghai, 200080, China.
Xinran QinDepartment of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University, School of Medicine, No.100 Haining Road, Shanghai, 200080, China.
Yi XuShanghai Eye Disease Prevention and Treatment Center/Shanghai Eye Hospital, Shanghai, China.
Lina LuShanghai Eye Disease Prevention and Treatment Center/Shanghai Eye Hospital, Shanghai, China.
Haidong ZouDepartment of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University, School of Medicine, No.100 Haining Road, Shanghai, 200080, China. zouhaidong@sjtu.edu.cn.ORCID http://orcid.org/0000-0002-6831-7560
Shanghai Jiao Tong University · CNShanghai Eye Disease Prevention & Treatment Center · CNShanghai Chest Hospital · CNSongjiang District Central Hospital · CN

Funding

Chinese National Key Research and Development Program 2021YFC2702100National Natural Science Foundation of China 82071012Shanghai engineering research center of precise diagnosis and treatment of eye diseases, Shanghai, China 19DZ2250100Shanghai General Hospital, Clinical Research CTCCR-2018Z01Shanghai Municipal Commission of health (public health system three-year plan-Key Subjects) GWV10.1-XK7The Project of Shanghai Shen Kang Hospital Development Centre SHDC2018110The Project of Shanghai Shen Kang Hospital Development Centre SHDC2020CR30538The Science and Technology Commission of Shanghai Municipality 20DZ1100200
6 · The paper itself

Abstract

purposeTo investigate the relationship between serum 12-Hydroxyeicosatetraenoic acid (12-HETE) and diabetic retinopathy (DR) in children with type 1 diabetes mellitus (T1DM) and adults with type 2 diabetes mellitus (T2DM).

methodsChildren from the Shanghai Children and Adolescent Diabetes Eye (SCADE) study and adults from the Shanghai Cohort Study of Diabetic Eye Disease (SCODE) were examined in 2021. Serum 12-HETE levels were detected and compared. Multivariate logistic regression was used to analyze the relationship between 12-HETE and the rate of DR in diabetic patients.

resultsThe child study included 4 patients with new-onset DR and 24 patients with T1DM without DR. In children with T1DM, the 12-HETE level was significantly higher in those with DR (P = 0.003). The adult study had two sets, for testing and verification. The test set included 28 patients with new-onset DR and 24 T2DM patients with a course of ≥ 20 years who had never developed DR. The verification set included 41 patients with DR, 50 patients without DR and 50 healthy controls. In the adult test set, the 12-HETE level was significantly higher in patients with DR than in those with T2DM without DR (P = 0.003). In the verification set, the 12-HETE level of patients with DR was significantly higher than that of patients without DR (P < 0.0001) and the healthy controls (P < 0.0001). Multivariate logistic regression indicated that 12-HETE was independently associated with DR in both children (odds ratio [OR] 1.06, 95% confidence interval [CI] 1.00-1.13, P = 0.041) and adults (test set [OR 9.26, 95% CI 1.77-48.59, P = 0.008], verification set [OR 10.49, 95% CI 3.23-34.05, P < 0.001]).

conclusionHigher serum 12-HETE levels are positively correlated with an increased risk of DR in children with T1DM and adults with T2DM.

Indexed as

Diabetes Mellitus, Type 1Diabetes Mellitus, Type 2Diabetic Retinopathy12-Hydroxy-5,8,10,14-eicosatetraenoic AcidAdolescentAdultChildChinaCohort StudiesHumansRisk Factors12-Hydroxy-5,8,10,14-eicosatetraenoic Acid12-HETEAdultChildrenDiabetes mellitusDiabetic retinopathy

Identifiers

PMID35962259
PMCPMC9374295
OpenAlexW4290878795

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.