Evidence map›Paper›PMID 35962176›Full record

ReviewStem cell reviews and reports2022

Drugs and Endogenous Factors as Protagonists in Neurogenic Stimulation.

Raphaela A Chiareli, Bruno L Marques, Gustavo A de Carvalho, Raysa T V de Souza, Pedro H G Santana, Helton C Santiago, Mauro C X Pinto, Alexander Birbrair, Ricardo C Parreira, Henning Ulrich and 1 more

Open access · greenAbstract readReview
PubMed Publisher
In one paragraph

Review in Stem cell reviews and reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Raphaela A ChiareliLaboratório de Neurofarmacologia E Neuroquímica, Departamento de Farmacologia, Instituto de Ciências Biológicas, Universidade Federal de Goiás, Goiânia, Goiás, Brazil.ORCID http://orcid.org/0000-0003-1784-4640
Bruno L MarquesLaboratório de Neurofarmacologia E Neuroquímica, Departamento de Farmacologia, Instituto de Ciências Biológicas, Universidade Federal de Goiás, Goiânia, Goiás, Brazil.ORCID http://orcid.org/0000-0001-6651-4512
Gustavo A de CarvalhoLaboratório de Neurofarmacologia E Neuroquímica, Departamento de Farmacologia, Instituto de Ciências Biológicas, Universidade Federal de Goiás, Goiânia, Goiás, Brazil.ORCID http://orcid.org/0000-0001-6762-0034
Raysa T V de SouzaCentro Universitário de Mineiros - UNIFIMES, Campus Trindade, Mineiros, GO, Brazil.ORCID http://orcid.org/0000-0002-7506-2607
Pedro H G SantanaCentro Universitário de Mineiros - UNIFIMES, Campus Trindade, Mineiros, GO, Brazil.ORCID http://orcid.org/0000-0002-2005-3711
Helton C SantiagoLaboratório de Sinalização Celular E Nanobiotecnologia, Departamento de Bioquímica E Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.ORCID http://orcid.org/0000-0002-5695-8256
Mauro C X PintoLaboratório de Neurofarmacologia E Neuroquímica, Departamento de Farmacologia, Instituto de Ciências Biológicas, Universidade Federal de Goiás, Goiânia, Goiás, Brazil.ORCID http://orcid.org/0000-0002-1680-8130
Alexander BirbrairDepartamento de Patologia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.ORCID http://orcid.org/0000-0003-1015-2561
Ricardo C ParreiraCentro Universitário de Mineiros - UNIFIMES, Campus Trindade, Mineiros, GO, Brazil.ORCID http://orcid.org/0000-0002-2769-7958
Henning UlrichLaboratório de Neurociências, Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, São Paulo, SP, Brazil.ORCID http://orcid.org/0000-0002-2114-3815
Rodrigo R ResendeLaboratório de Sinalização Celular E Nanobiotecnologia, Departamento de Bioquímica E Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil. rrresende@hotmail.com.ORCID http://orcid.org/0000-0002-2003-0739
Universidade Federal de Goiás · BRUniversidade Federal de Minas Gerais · BRUniversidade de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neurogenesis is a biological process characterized by new neurons formation from stem cells. For decades, it was believed that neurons only multiplied during development and in the postnatal period but the discovery of neural stem cells (NSCs) in mature brain promoted a revolution in neuroscience field. In mammals, neurogenesis consists of migration, differentiation, maturation, as well as functional integration of newborn cells into the pre-existing neuronal circuit. Actually, NSC density drops significantly after the first stages of development, however in specific places in the brain, called neurogenic niches, some of these cells retain their ability to generate new neurons and glial cells in adulthood. The subgranular (SGZ), and the subventricular zones (SVZ) are examples of regions where the neurogenesis process occurs in the mature brain. There, the potential of NSCs to produce new neurons has been explored by new advanced methodologies and in neuroscience for the treatment of brain damage and/or degeneration. Based on that, this review highlights endogenous factors and drugs capable of stimulating neurogenesis, as well as the perspectives for the use of NSCs for neurological and neurodegenerative diseases.

Indexed as

Neural Stem CellsNeurogenesisAdultAnimalsHumansInfant, NewbornLateral VentriclesMammalsNeurogliaNeuronsBone morphogenetic proteinsCell differentiationNeural stem cellsNeurogenesisNeurotrophins, NotchSonic hedgehogWnt wingless-related

Identifiers

PMID35962176
OpenAlexW4290964223

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.