Evidence map›Paper›PMID 35961998›Full record

ArticleScientific reports2022

Bio-impedance method to monitor colon motility response to direct distal colon stimulation in anesthetized pigs.

Yushan Wang, Po-Min Wang, Muriel Larauche, Million Mulugeta, Wentai Liu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 91% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Yushan WangDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA, USA.
Po-Min WangDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA, USA.
Muriel LaraucheVatche and Tamar Manoukian Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine, CURE: Digestive Diseases Research Core Center (DDRCC), Center for Neurobiology of Stress and Resilience (CNSR), University of California, Los Angeles, Los Angeles, CA, USA.
Million MulugetaVatche and Tamar Manoukian Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine, CURE: Digestive Diseases Research Core Center (DDRCC), Center for Neurobiology of Stress and Resilience (CNSR), University of California, Los Angeles, Los Angeles, CA, USA. millionmulugeta@mednet.ucla.edu.
Wentai LiuDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA, USA. wentai@ucla.edu.
University of California, Los Angeles · USVA Greater Los Angeles Healthcare System · US

Funding

Pilot and Feasibility ProgramP30DK041301 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ROZENGURT, JUAN ENRIQUE · 1990 to 2019
$18.0M
Comprehensive Structural and Functional Mapping of Mammalian Colonic Nervous SystemOT2OD024899 · OD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MULUGETA, MILLION, TACHE, YVETTE FRANCE · 2017 to 2021
$13.1M
Structural and functional mapping of visceral pain afferent neurocircuitries of the colorectum and bladder in preclinical modelsU01NS113871 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MULUGETA, MILLION · 2019 to 2021
$2.1M
NIDDK NIH HHS P30 DK041301NIH HHS OT2 OD024899NIH HHS P30 DK 41301NINDS NIH HHS U01 NS113871
6 · The paper itself

Abstract

Electrical stimulation has been demonstrated as an alternative approach to alleviate intractable colonic motor disorders, whose effectiveness can be evaluated through colonic motility assessment. Various methods have been proposed to monitor the colonic motility and while each has contributed towards better understanding of colon motility, a significant limitation has been the spatial and temporal low-resolution colon motility data acquisition and analysis. This paper presents the study of employing bio-impedance characterization to monitor colonic motor activity. Direct distal colon stimulation was undertaken in anesthetized pigs to validate the bio-impedance scheme simultaneous with luminal manometry monitoring. The results indicated that the significant decreases of bio-impedance corresponded to strong colonic contraction in response to the electrical stimulation in the distal colon. The magnitude/power of the dominant frequencies of phasic colonic contractions identified at baseline (in the range 2-3 cycles per minute (cpm)) were increased after the stimulation. In addition, positive correlations have been found between bio-impedance and manometry. The proposed bio-impedance-based method can be a viable candidate for monitoring colonic motor pattern with high spatial and temporal resolution. The presented technique can be integrated into a closed-loop therapeutic device in order to optimize its stimulation protocol in real-time.

Indexed as

Colonic DiseasesGastrointestinal MotilityAnimalsColonElectric ImpedanceManometrySwine

Identifiers

PMID35961998
PMCPMC9374686
OpenAlexW4290829887

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.