ArticleNature communications2022
Structural basis for receptor selectivity and inverse agonism in S1P
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Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
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Who cites it
13 citing papers in PubMed, 22 citations in OpenAlex.
- Decoding the S1P-S1PR axis in cancer: Mechanisms, pathways and therapeutic horizons (Review).Biomedical reports · 2026Review
- Sphingosine-1-Phosphate-derived 2-Hexadecenal is a central mediator of ocular neovascularization by inhibiting Sphingosine-1-Phosphate receptor 5.Nature communications · 2026Article
- Structural insights into subtype-specific agonist recognition by sphingosine-1-phosphate receptors.PLoS biology · 2026Article
- Lipid metabolism in homeostasis and disease.Signal transduction and targeted therapy · 2026Review
- Structural insights into the G-protein subtype selectivity revealed by human sphingosine-1-phosphate receptor 3-GProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Design and Synthesis of Novel PET Radiotracers for Imaging Sphingosine-1-Phosphate Receptor 5 (S1PR5) in the Brain.Journal of medicinal chemistry · 2025Article
- Unlocking GPCR-ligand interactions: Measuring binding affinities with thermal shift assay.Protein science : a publication of the Protein Society · 2025Article
- Regulation of cellular and systemic sphingolipid homeostasis.Nature reviews. Molecular cell biology · 2024Review
- Multiple system atrophy: an update and emerging directions of biomarkers and clinical trials.Journal of neurology · 2024Review
- The Current Landscape in the Development of Small-molecule Modulators Targeting Sphingosine-1-phosphate Receptors to Treat Neurodegenerative Diseases.Current topics in medicinal chemistry · 2024Review
- Structural basis for ligand recognition and signaling of the lysophosphatidylserine receptors GPR34 and GPR174.PLoS biology · 2023Article
- Molecular and neuroimmune pharmacology of S1P receptor modulators and other disease-modifying therapies for multiple sclerosis.Pharmacology & therapeutics · 2023Review
- Sphingosine-1-Phosphate Signaling in Cardiovascular Diseases.Biomolecules · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
31 authors at 9 institutions in 8 countries.
Elizaveta Lyapina *Research Сenter for Molecular Mechanisms of Aging and Age-related Diseases, Moscow Institute of Physics and Technology, Dolgoprudny, 141701, Russia.ORCID 0000-0003-0719-8497
Egor Marin *Research Сenter for Molecular Mechanisms of Aging and Age-related Diseases, Moscow Institute of Physics and Technology, Dolgoprudny, 141701, Russia.ORCID 0000-0003-2369-1732
Anastasiia Gusach *Research Сenter for Molecular Mechanisms of Aging and Age-related Diseases, Moscow Institute of Physics and Technology, Dolgoprudny, 141701, Russia.ORCID 0000-0002-2594-8573
Philipp OrekhovResearch Сenter for Molecular Mechanisms of Aging and Age-related Diseases, Moscow Institute of Physics and Technology, Dolgoprudny, 141701, Russia.ORCID 0000-0003-4078-4762
Andrey GerasimovVyatka State University, Kirov, 610020, Russia.ORCID 0000-0002-3897-0622
Aleksandra LugininaResearch Сenter for Molecular Mechanisms of Aging and Age-related Diseases, Moscow Institute of Physics and Technology, Dolgoprudny, 141701, Russia.ORCID 0000-0003-2697-456X
Daniil VakhrameevResearch Сenter for Molecular Mechanisms of Aging and Age-related Diseases, Moscow Institute of Physics and Technology, Dolgoprudny, 141701, Russia.ORCID 0000-0002-1430-0261
Margarita ErgashevaResearch Сenter for Molecular Mechanisms of Aging and Age-related Diseases, Moscow Institute of Physics and Technology, Dolgoprudny, 141701, Russia.
Margarita KovalevaResearch Сenter for Molecular Mechanisms of Aging and Age-related Diseases, Moscow Institute of Physics and Technology, Dolgoprudny, 141701, Russia.ORCID 0000-0002-0753-3905
Georgii KhusainovResearch Сenter for Molecular Mechanisms of Aging and Age-related Diseases, Moscow Institute of Physics and Technology, Dolgoprudny, 141701, Russia.
Polina KhornResearch Сenter for Molecular Mechanisms of Aging and Age-related Diseases, Moscow Institute of Physics and Technology, Dolgoprudny, 141701, Russia.
Mikhail ShevtsovResearch Сenter for Molecular Mechanisms of Aging and Age-related Diseases, Moscow Institute of Physics and Technology, Dolgoprudny, 141701, Russia.
Kirill KovalevResearch Сenter for Molecular Mechanisms of Aging and Age-related Diseases, Moscow Institute of Physics and Technology, Dolgoprudny, 141701, Russia.
Sergey BukhdrukerResearch Сenter for Molecular Mechanisms of Aging and Age-related Diseases, Moscow Institute of Physics and Technology, Dolgoprudny, 141701, Russia.
Ivan OkhrimenkoResearch Сenter for Molecular Mechanisms of Aging and Age-related Diseases, Moscow Institute of Physics and Technology, Dolgoprudny, 141701, Russia.ORCID 0000-0002-1053-2778
Petr PopovResearch Сenter for Molecular Mechanisms of Aging and Age-related Diseases, Moscow Institute of Physics and Technology, Dolgoprudny, 141701, Russia.
Hao HuDepartment of Physics, Arizona State University, Tempe, AZ, 85281, USA.ORCID 0000-0003-3472-0404
Uwe WeierstallDepartment of Physics, Arizona State University, Tempe, AZ, 85281, USA.
Wei LiuCancer Center and Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI, 53226, USA.ORCID 0000-0002-7568-5521
Yunje ChoDepartment of Life Science, Pohang University of Science and Technology, Pohang, Republic of Korea.ORCID 0000-0001-6481-1716
Ivan GushchinResearch Сenter for Molecular Mechanisms of Aging and Age-related Diseases, Moscow Institute of Physics and Technology, Dolgoprudny, 141701, Russia.ORCID 0000-0002-5348-6070
Andrey RogachevResearch Сenter for Molecular Mechanisms of Aging and Age-related Diseases, Moscow Institute of Physics and Technology, Dolgoprudny, 141701, Russia.ORCID 0000-0003-2872-7976
Gleb BourenkovEuropean Molecular Biology Laboratory, Hamburg unit c/o DESY, Hamburg, Germany.ORCID 0000-0002-2617-5920
Sehan ParkPohang Accelerator Laboratory, POSTECH, Pohang, 37673, Republic of Korea.
Gisu ParkPohang Accelerator Laboratory, POSTECH, Pohang, 37673, Republic of Korea.
Hyo Jung HyunPohang Accelerator Laboratory, POSTECH, Pohang, 37673, Republic of Korea.
Jaehyun ParkPohang Accelerator Laboratory, POSTECH, Pohang, 37673, Republic of Korea.
Valentin GordeliyInstitut de Biologie Structurale (IBS), Université Grenoble Alpes, CEA, CNRS, Grenoble, 38400, France.
Valentin BorshchevskiyResearch Сenter for Molecular Mechanisms of Aging and Age-related Diseases, Moscow Institute of Physics and Technology, Dolgoprudny, 141701, Russia. borshchevskiy.vi@phystech.edu.ORCID 0000-0003-4398-9712
Alexey MishinResearch Сenter for Molecular Mechanisms of Aging and Age-related Diseases, Moscow Institute of Physics and Technology, Dolgoprudny, 141701, Russia. mishinalexey@phystech.edu.ORCID 0000-0003-3759-380X
Vadim CherezovBridge Institute, Department of Chemistry, University of Southern California, Los Angeles, CA, 90089, USA. cherezov@usc.edu.ORCID 0000-0002-5265-3914
Moscow Institute of Physics and Technology · RUPohang University of Science and Technology · KRArizona State University · USCentre National de la Recherche Scientifique · FREuropean Molecular Biology Laboratory · DEMedical College of Wisconsin · USSkolkovo Institute of Science and Technology · RUUniversity of Southern California · USVyatka State University · RU
Funding
No grant is acknowledged in the PubMed record.
Abstract
The bioactive lysophospholipid sphingosine-1-phosphate (S1P) acts via five different subtypes of S1P receptors (S1PRs) - S1P
Indexed as
Receptors, LysosphingolipidSphingosineHumansImmune SystemLysophospholipidsLysophospholipidsReceptors, LysosphingolipidSphingosinesphingosine 1-phosphate
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