ArticleZeitschrift fur medizinische Physik2023
Single-time-point estimation of absorbed doses in PRRT using a non-linear mixed-effects model.
Article in Zeitschrift fur medizinische Physik, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 28 citations in OpenAlex.
- Outcome-driven dosimetry optimization for [European journal of nuclear medicine and molecular imaging · 2026Article
- Towards practical radiopharmaceutical treatment planning: a review of dosimetry simplification techniques.Theranostics · 2026Review
- Non-linear mixed-effects modelling and population-based model selection forEJNMMI physics · 2025Article
- Accuracy and precision analyses of single-time-point dosimetry utilising physiologically-based pharmacokinetic modelling and non-linear mixed-effects modelling.EJNMMI physics · 2025Article
- Digital twins in nuclear medicine: A proposition of a modular pipeline for dosimetry protocol optimization in molecular radiotherapy.Computational and structural biotechnology journal · 2025Article
- Targeted radioligand therapy: physics and biology, internal dosimetry and other practical aspects duringTheranostics · 2025Review
- Population pharmacokinetic modeling in radiopharmaceutical therapy: a review.Frontiers in nuclear medicine · 2025Review
- Population-based model selection for an accurate estimation of time-integrated activity using non-linear mixed-effects modelling.Zeitschrift fur medizinische Physik · 2024Article
- Estimation of kidney doses from [EJNMMI physics · 2024Article
- A review of 177Lu dosimetry workflows: how to reduce the imaging workloads?EJNMMI physics · 2024Review
- Single-Time-Point Imaging for Dosimetry After [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023Article
- Accuracy and uncertainty analysis of reduced time point imaging effect on time-integrated activity forEJNMMI research · 2023Article
- Accuracy and uncertainty analysis of reduced time point imaging effect on time-integrated activity for 177Lu-DOTATATE PRRT in clinical patients and realistic simulations.Research square · 2023Article
- Single-time-point dosimetry using model selection and nonlinear mixed-effects modelling: a proof of concept.EJNMMI physics · 2023Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionEstimation of accurate time-integrated activity coefficients (TIACs) and radiation absorbed doses (ADs) is desirable for treatment planning in peptide-receptor radionuclide therapy (PRRT). This study aimed to investigate the accuracy of a simplified dosimetry using a physiologically-based pharmacokinetic (PBPK) model, a nonlinear mixed effect (NLME) model, and single-time-point imaging to calculate the TIACs and ADs of MATERIALS &
methodsBiokinetic data of
resultsUsing the PBPK and NLME models and the biokinetic measurements resulted in a good fit based on visual inspection of the fitted curves and the coefficient of variation CV of the fitted parameters (<50%). T4 was identified being the time point with a relatively low median and range of TIACs RDs, i.e., 5 [1, 21]% and 2 [-15, 21]% for kidneys and tumors, respectively. T4 was found to be the time point with the lowest joint root mean square error RMSE SUMMARY: In this study, we introduced a simplified calculation of TIACs/ADs using a PBPK model, an NLME model, and a single-time-point measurement. Our results suggest a single measurement might be used to calculate TIACs/ADs in the kidneys and tumors during PRRT.
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