Evidence map›Paper›PMID 35961784›Full record

ReviewJournal of medical genetics2022

TMPRSS3 expression is limited in spiral ganglion neurons: implication for successful cochlear implantation.

Yuan-Siao Chen, Ernesto Cabrera, Brady J Tucker, Timothy J Shin, Jasmine V Moawad, Douglas J Totten, Kevin T Booth, Rick F Nelson

Open access · greenAbstract readReview
In one paragraph

Review in Journal of medical genetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Novel splice-site variants inFrontiers in genetics · 2026
    Article
  3. Article
  4. [Expert consensus on prognostic evaluation of cochlear implantation in hereditary hearing loss].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2025
    Article
  5. Cochlear Implantation Outcomes in Genotyped Subjects with Sensorineural Hearing Loss.Journal of the Association for Research in Otolaryngology : JARO · 2025
    Article
  6. Article
  7. [Late-onset hereditary hearing loss caused byLin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2024
    Article
  8. Article
  9. Review
  10. Article
  11. Stable long-term outcomes after cochlear implantation in subjects with TMPRSS3 associated hearing loss: a retrospective multicentre study.Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale · 2023
    Article
  12. Selection of viral capsids and promoters affects the efficacy of rescue ofMolecular therapy. Methods & clinical development · 2023
    Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Yuan-Siao ChenDepartment of Otolaryngology-Head and Neck Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA.ORCID 0000-0003-3435-7190
Ernesto CabreraDepartment of Otolaryngology-Head and Neck Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA.ORCID 0000-0001-6701-7163
Brady J TuckerDepartment of Otolaryngology-Head and Neck Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Timothy J ShinDepartment of Otolaryngology-Head and Neck Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA.ORCID 0000-0001-7460-9458
Jasmine V MoawadDepartment of Otolaryngology-Head and Neck Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Douglas J TottenDepartment of Otolaryngology-Head and Neck Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA.ORCID 0000-0002-0665-9653
Kevin T BoothNeurobiology, Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0003-3061-3652
Rick F NelsonDepartment of Otolaryngology-Head and Neck Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA ricnelso@iupui.edu.ORCID 0000-0001-5749-6383
Indiana University School of MedicineHarvard University · US

Funding

TRAINING GRANT IN GENETICST32GM007748 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI Anne O'Donnell-Luria, Louise Wilkins-Haug · 1985 to 2026
$12.0M
Mechanisms of Mammalian Genetic Hearing LossR01DC020574 · NIDCD · INDIANA UNIVERSITY INDIANAPOLIS · PI Rick F Nelson · 2023 to 2026
$2.4M
Genetically Mediated Hair Cell Degeneration in 3D Inner Ear OrganoidsK08DC016034 · NIDCD · INDIANA UNIVERSITY INDIANAPOLIS · PI NELSON, RICK F · 2017 to 2021
$894k
NIDCD NIH HHS K08 DC016034NIDCD NIH HHS R01 DC020574NIGMS NIH HHS T32 GM007748
6 · The paper itself

Abstract

backgroundIt is well established that biallelic mutations in transmembrane protease, serine 3 (

methodsA literature review was performed to identify all published cases of patients with

resultsIn aggregate, 27 patients (30 total CI ears) with

conclusionThe clinical features after CI and physiological expression of

Indexed as

Cochlear ImplantationDeafnessHearing LossAdultAnimalsHumansMembrane ProteinsMiceNeoplasm ProteinsNeuronsSerine EndopeptidasesSpiral GanglionMembrane ProteinsNeoplasm ProteinsSerine EndopeptidasesTMPRSS3 protein, humanclinical decision-makingdisease managementgene expression profilingotolaryngologyotorhinolaryngologic diseases

Identifiers

PMID35961784
PMCPMC10245338
OpenAlexW4290851461

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.