Evidence map›Paper›PMID 35961564›Full record

Observational studyUrology2022

Long-Term Symptom Trajectories in Urologic Chronic Pelvic Pain Syndrome: A MAPP Research Network Study.

Catherine S Bradley, Robert Gallop, Siobhan Sutcliffe, Karl J Kreder, H Henry Lai, J Quentin Clemens, Bruce D Naliboff, Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network

Open access · greenAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Urology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Chronic Primary Pelvic Pain Syndrome in Men.Deutsches Arzteblatt international · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Catherine S BradleyDepartment of Obstetrics and Gynecology, Carver College of Medicine, University of Iowa, Iowa City, IA. Electronic address: catherine-bradley@uiowa.edu.
Robert GallopDepartment of Mathematics, Applied Statistics Program, West Chester University, West Chester, PA.
Siobhan SutcliffeDepartments of Surgery (Public Health Sciences) and Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, MO.
Karl J KrederDepartment of Urology, Carver College of Medicine, University of Iowa, Iowa City, IA.
H Henry LaiDepartments of Surgery (Urology) and Anesthesiology, Washington University School of Medicine, St Louis, MO.
J Quentin ClemensDepartment of Urology, University of Michigan, Ann Arbor, MI.
Bruce D NaliboffDepartment of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA.
Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network
University of Iowa · USWashington University in St. Louis · USUniversity of California, Los Angeles · USUniversity of Michigan · USWest Chester University · US

Funding

MAPP Research NetworkU01DK082316 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI LANDIS, J RICHARD · 2008 to 2018
$17.2M
Role of CNS in Modulation of Pelvic Pain SyndromeU01DK082342 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI KLUMPP, DAVID J · 2008 to 2021
$10.5M
Urology Chronic Pelvic Pain Longitudinal Symptom Patterns StudyU01DK082344 · NIDDK · UNIVERSITY OF IOWA · PI KREDER, KARL J · 2008 to 2021
$9.8M
University of Michigan MAPP Research Network Discovery SiteU01DK082345 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CLAUW, DANIEL J, CLEMENS, J. QUENTIN · 2008 to 2021
$9.7M
Neurobiological endophenotypes & gene-environment interactions in IC/PBS & in aU01DK082370 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KUTCH, JASON J., MAYER, EMERAN A · 2008 to 2021
$9.2M
WSU Urologic Chronic Pelvic Pain Syndromes Discovery CenterU01DK082325 · NIDDK · WASHINGTON STATE UNIVERSITY · PI BOGIC, MARIJA · 2008 to 2021
$9.0M
Washington University MAPP Network Discovery SiteU01DK082315 · NIDDK · WASHINGTON UNIVERSITY · PI LAI, HING HUNG HENRY · 2008 to 2021
$9.0M
MAPP Research Network Tissue Analysis and Technology CoreU01DK082333 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI LUCIA, M. SCOTT · 2008 to 2018
$6.1M
Limited Competition for Continuation of the MAPP-RN DCCU24DK082316 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI LANDIS, J RICHARD · 2019 to 2021
$4.9M
Expansion of the MAPP Research Network: Microbial and Biopsychosocial ContributioU01DK103271 · NIDDK · QUEEN'S UNIVERSITY AT KINGSTON · PI NICKEL, JOHN CURTIS · 2014 to 2018
$1.2M
Discovery, Validation and Clinical Application of Novel, Non-Invasive BiomarkersU01DK103227 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI LEE, RICHARD SANG-YONG, MOSES, MARSHA A · 2014 to 2018
$1.2M
Microbiome and Proteome As Predictive Biomarkers of UCPPSU01DK103260 · NIDDK · CEDARS-SINAI MEDICAL CENTER · PI ANGER, JENNIFER TASH, FREEMAN, MICHAEL R · 2014 to 2018
$1.2M
NIDDK NIH HHS U01 DK082315NIDDK NIH HHS U01 DK082316NIDDK NIH HHS U01 DK082325NIDDK NIH HHS U01 DK082333NIDDK NIH HHS U01 DK082342NIDDK NIH HHS U01 DK082344NIDDK NIH HHS U01 DK082345NIDDK NIH HHS U01 DK082370NIDDK NIH HHS U01 DK103227NIDDK NIH HHS U01 DK103260NIDDK NIH HHS U01 DK103271NIDDK NIH HHS U24 DK082316
6 · The paper itself

Abstract

objectiveTo characterize Urologic Chronic Pelvic Pain Syndrome (UCPPS) pain and urinary symptom trajectories with up to 9 years of follow-up and evaluate whether initial 1-year trajectories are associated with longer-term changes. MATERIALS AND

methodsData were analyzed from the Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Network's prospective observational protocols including the Epidemiology and Phenotyping Study (EPS; baseline to Year 1), EPS Extension (EXT; Years 1-5), and Symptom Patterns Study (SPS: 3-year study; Years 3-9). Adults with Interstitial Cystitis/Bladder Pain Syndrome or Chronic Prostatitis/Chronic Pelvic Pain Syndrome provided patient-reported assessments biweekly (EPS), every 4 months (EXT), or quarterly (SPS). Primary outcomes were composite pain (0-28) and urinary (0-25) severity scores. Multi-phase mixed effects models estimated outcomes over time, adjusted for baseline severity and stratified by EPS symptom trajectory.

results163 participants (52% women; mean ± SD age 46.4 ± 16.1 years) completed EPS and enrolled in EXT; 67 also enrolled in SPS. Median follow-up was 4.6 years (range 1.3-9.0). After 1 year: 27.6%, 44.8% and 27.6% and 27.0%, 38.0% and 35.0% were improved, stable or worse in pain and urinary symptom severity, respectively. On average, pain and urinary symptom scores did not change further during EXT and SPS periods.

conclusionsWomen and men with UCPPS showed remarkable stability in pain and urinary symptom severity for up to 9 years, irrespective of their initial symptom trajectory, suggesting UCPPS is a chronic condition with stable symptoms over multiple years of follow-up.

Indexed as

Chronic PainCystitis, InterstitialGenital Diseases, FemaleProstatitisAdultFemaleHumansMaleMiddle AgedPelvic PainSyndrome

Identifiers

PMID35961564
PMCPMC10590538
OpenAlexW4290729791

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.