Evidence map›Paper›PMID 35961524›Full record

ArticleNeuroscience2022

Influence of Effort-based Reward Training on Neuroadaptive Cognitive Responses: Implications for Preclinical Behavioral Approaches for Depressive Symptoms.

Emily Ploppert, Joanna Jacob, Ana Deutsch, Sally Watanabe, Katherine Gillenwater, Alison Choe, George B Cruz, Ericka Cabañas, Michelle A Vasquez, Zaid Ayaz and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Emily PloppertDept of Psychology, University of Richmond, Richmond, VA, USA.
Joanna JacobDept of Psychology, University of Richmond, Richmond, VA, USA.
Ana DeutschDept of Psychology, University of Richmond, Richmond, VA, USA.
Sally WatanabeDept of Psychology, University of Richmond, Richmond, VA, USA.
Katherine GillenwaterDept of Psychology, University of Richmond, Richmond, VA, USA.
Alison ChoeDept of Psychology, University of Richmond, Richmond, VA, USA.
George B CruzDept of Biology, SUNY Old Westbury, Old Westbury, NY, USA; SUNY Neuroscience Research Institute, Old Westbury, NY, USA.
Ericka CabañasDept of Biology, SUNY Old Westbury, Old Westbury, NY, USA; SUNY Neuroscience Research Institute, Old Westbury, NY, USA.
Michelle A VasquezSUNY Neuroscience Research Institute, Old Westbury, NY, USA; Dept Chemistry & Physics, SUNY Old Westbury, Old Westbury, NY, USA.
Zaid AyazDept of Biology, SUNY Old Westbury, Old Westbury, NY, USA; SUNY Neuroscience Research Institute, Old Westbury, NY, USA.
Lorenz S NeuwirthSUNY Neuroscience Research Institute, Old Westbury, NY, USA; Dept of Psychology, SUNY Old Westbury, Old Westbury, NY, USA.
Kelly LambertDept of Psychology, University of Richmond, Richmond, VA, USA. Electronic address: klambert@richmond.edu.
University of Richmond · USSUNY Old Westbury · US

Funding

Deconstructing Depressogenic Susceptibility and Emotional Resilience in RatsR15MH117628 · NIMH · UNIVERSITY OF RICHMOND · PI LAMBERT, KELLY G · 2019 to 2019
$437k
NIMH NIH HHS R15 MH117628
6 · The paper itself

Abstract

Despite the presence of multiple pharmacotherapeutic options, incidence rates for depressive disorders continue to rise. Nonpharmacological approaches (e.g., cognitive and behavioral therapies) exhibit encouraging efficacy rates; however, a lack of preclinical models has prevented progress in the identification of relevant neurobiological mechanisms of these approaches. Accordingly, the effort-based reward (EBR) preclinical model exposes rats to response-outcome (R-O) contingencies and provides an opportunity to investigate behavioral clinical approaches. In the current study, male and female rats were assigned to either an EBR contingent- or noncontingent-trained group and exposed to 7 weeks of training. Neuroadaptive cognitive responses were assessed in a cognitive uncertainty task (UT) and an object pattern separation task (OPST). Although no significant effects of EBR were observed in the UT, EBR contingent-trained rats approached the novel panel in the most difficult trial of the OPST faster than the noncontingent-trained group. Additionally, female EBR contingent-trained rats exhibited increased engagement with the novel stimulus panel across all trials. Examination of brain-derived neurotrophic factor (BDNF) in the lateral habenula (LHb), a putative neurobiological target for depressive symptoms, revealed lower BDNF immunoreactivity in EBR contingent-trained rats. Females in both training groups exhibited higher dehydroepiandrosterone/cortisol (DHEA/CORT) ratios, suggesting, along with the increased engagement with novel stimulus panels, that female rats may be more responsive to EBR contingency training than males. Together, these results suggest that EBR contingency training offers promise as a preclinical rat model for behavioral therapeutic interventions for depressive symptoms leading to a clearer understanding of putative neurobiological mechanisms.

Indexed as

Brain-Derived Neurotrophic FactorDepressionAnimalsCognitionFemaleMaleRatsRats, Long-EvansRewardBrain-Derived Neurotrophic Factorbrain-derived neurotrophic factor (BDNF)Dehydroepiandrosterone (DHEA)Depressive symptomsEffort-based Reward (EBR)Lateral habenula (LHb)Preclinical model of depression

Identifiers

PMID35961524
PMCPMC9464718
OpenAlexW4291285469

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.