ArticleThe Plant cell2022
Type one protein phosphatase regulates fixed-carbon starvation-induced autophagy in Arabidopsis.
Article in The Plant cell, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 35 citations in OpenAlex.
- Chloroplast Protein Degradation Pathways During Leaf Senescence: Coordination and Roles in Nitrogen Remobilization.Plants (Basel, Switzerland) · 2026Review
- Protein Tyrosine Phosphatase Regulates Sporulation, Trap Morphogenesis, Stress Responses, and Secondary Metabolism inJournal of fungi (Basel, Switzerland) · 2026Article
- The protein phosphatase OsPP1a dephosphorylates and stabilizes CatC to scavenge excess HPlant communications · 2026Article
- Type one protein phosphatases (TOPPs) catalyze EIN2 dephosphorylation to regulate ethylene signaling inScience advances · 2026Article
- Genome-wide identification and functional characterization of PP2C genes in the wild relative of sweet potato Ipomoea trifida.BMC plant biology · 2025Article
- Autophagy deficiency confers freezing tolerance in Arabidopsis thaliana.BMC plant biology · 2025Article
- Genome-Wide Identification ofPlants (Basel, Switzerland) · 2025Article
- Article
- A CPF-like phosphatase module links transcription termination to chromatin silencing.Molecular cell · 2024Article
- MAPK20-mediated ATG6 phosphorylation is critical for pollen development inHorticulture research · 2024Article
- Autophagy in plants.Autophagy reports · 2024Review
- Studying plant autophagy: challenges and recommended methodologies.Advanced biotechnology · 2023Review
- Transcriptional and post-translational regulation of plant autophagy.Journal of experimental botany · 2023Review
- 14-3-3 proteins contribute to autophagy by modulating SINAT-mediated degradation of ATG13.The Plant cell · 2022Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Autophagy, a conserved pathway that carries out the bulk degradation of cytoplasmic material in eukaryotic cells, is critical for plant physiology and development. This process is tightly regulated by ATG13, a core component of the ATG1 kinase complex, which initiates autophagy. Although ATG13 is known to be dephosphorylated immediately after nutrient starvation, the phosphatase regulating this process is poorly understood. Here, we determined that the Arabidopsis (Arabidopsis thaliana) septuple mutant (topp-7m) and octuple mutant (topp-8m) of TYPE ONE PROTEIN PHOSPHATASE (TOPP) exhibited significantly reduced tolerance to fixed-carbon (C) starvation due to compromised autophagy activity. Genetic analysis placed TOPP upstream of autophagy. Interestingly, ATG13a was found to be an interactor of TOPP. TOPP directly dephosphorylated ATG13a in vitro and in vivo. We identified 18 phosphorylation sites in ATG13a by LC-MS. Phospho-dead ATG13a at these 18 sites significantly promoted autophagy and increased the tolerance of the atg13ab mutant to fixed-C starvation. The dephosphorylation of ATG13a facilitated ATG1a-ATG13a complex formation. Consistently, the recruitment of ATG13a for ATG1a was markedly inhibited in topp-7m-1. Finally, TOPP-controlled dephosphorylation of ATG13a boosted ATG1a phosphorylation. Taken together, our study reveals the crucial role of TOPP in regulating autophagy by stimulating the formation of the ATG1a-ATG13a complex by dephosphorylating ATG13a in Arabidopsis.
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