Evidence map›Paper›PMID 35960816›Full record

ArticleAngewandte Chemie (International ed. in English)2022

Palladium-Catalyzed Aryldifluoromethylation of Aryl Halides with Aryldifluoromethyl Trimethylsilanes.

Kyoungmin Choi, Michael G Mormino, Eric D Kalkman, John Park, John F Hartwig

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kyoungmin ChoiDepartment of Chemistry, University of California, Berkeley, CA 94720, USA.
Michael G MorminoDepartment of Chemistry, University of California, Berkeley, CA 94720, USA.
Eric D KalkmanDepartment of Chemistry, University of California, Berkeley, CA 94720, USA.
John ParkDepartment of Chemistry, University of California, Berkeley, CA 94720, USA.
John F HartwigDepartment of Chemistry, University of California, Berkeley, CA 94720, USA.ORCID 0000-0002-4157-468X

Funding

High Performance Computing Cluster for Public Health Driven Molecular Science - Core FacilityS10OD023532 · OD · UNIVERSITY OF CALIFORNIA BERKELEY · PI DURKIN, KATHLEEN A · 2017 to 2017
$434k
Acquisition of a Cryoprobe and Related Accessories for a 600 MHz NMR Spectrometer to Support Health Research Activities at the University of California, BerkeleyS10OD024998 · OD · UNIVERSITY OF CALIFORNIA BERKELEY · PI HARTWIG, JOHN F · 2018 to 2018
$265k
NIH HHS S10 OD023532NIH HHS S10 OD024998
6 · The paper itself

Abstract

Diaryl difluoromethanes are valuable targets for medicinal chemistry because they are bioisosteres of diaryl ethers and can function as replacements for diaryl methane, ketone, and sulfone groups. However, methods to prepare diaryl difluoromethanes are scarce, especially methods starting from abundant aryl halides. We report the Pd-catalyzed aryldifluoromethylation of aryl halides with aryldifluoromethyl trimethylsilanes (TMSCF

Indexed as

PalladiumSilanesCarbonCatalysisCobaltEthersFluorineHydrocarbons, FluorinatedKetonesLigandsMethaneSulfonesCarbonCobaltdifluoromethaneEthersFluorineHydrocarbons, FluorinatedKetonesLigandsMethanePalladiumSilanesSulfonesAlkylationCross-CouplingFluorinePalladiumSynthetic Methods

Identifiers

PMID35960816
PMCPMC9530024

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.