ArticleScience advances2022
Bioinspired large Stokes shift small molecular dyes for biomedical fluorescence imaging.
Article in Science advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
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- Advances in luminescence-based tracing technologies: applications and future perspectives.Biodesign research · 2026Review
- Design, synthesis, and in vitro and in vivo anticancer activity of mitochondrial targeted ferulic acid derivatives.Molecular diversity · 2026Article
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- Triple-Functional CuAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Near-infrared II cyanine fluorophores with large stokes shift engineered by regulating respective absorption and emission.Nature communications · 2025Article
- Rabies Virus Targeting NIR-II Phototheranostics.Journal of the American Chemical Society · 2025Article
- pH-responsive supramolecular switch of a rationally designed dipyrroethene-based chromophore.Chemical science · 2025Article
- Amphiphilic hemicyanine molecular probes crossing the blood-brain barrier for intracranial optical imaging of glioblastoma.Science advances · 2025Article
- Rapid determination of chemical losses in a microplate bioassay using fluorescence spectroscopy.Analytical methods : advancing methods and applications · 2025Article
- Breaking the blue barrier of nucleobase fluorescence emission with dicyanovinyl-based uracil molecular rotor probes.RSC advances · 2024Article
- Planar-Twisted Molecular Engineering for Modulating the Fluorescence Brightness of NIR-II Fluorophores with a Donor-Acceptor-Donor Skeleton.International journal of molecular sciences · 2024Article
- Emerging Thermosensitive Probes Based on Triamino-Phenazinium Dyes.Molecules (Basel, Switzerland) · 2024Article
- Enzyme-activatable charge transfer in gold nanoclusters.Chemical science · 2024Article
- Enhanced optical imaging and fluorescent labeling for visualizing drug molecules within living organisms.Acta pharmaceutica Sinica. B · 2024Review
- PyrAtes: Modular Organic Salts with Large Stokes Shifts for Fluo-rescence Microscopy.Angewandte Chemie (International ed. in English) · 2024Article
- Biomimetic chiral hydrogen-bonded organic-inorganic frameworks.Nature communications · 2024Article
- Albumin-seeking dyes with adjustable assembliesTheranostics · 2024Article
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Long Stokes shift dyes that minimize cross-talk between the excitation source and fluorescent emission to improve the signal-to-background ratio are highly desired for fluorescence imaging. However, simple small molecular dyes with large Stokes shift (more than 120 nanometers) and near-infrared (NIR) emissions have been rarely reported so far. Here, inspired by the chromophore chemical structure of fluorescent proteins, we designed and synthesized a series of styrene oxazolone dyes (SODs) with simple synthetic methods, which show NIR emissions (>650 nanometers) with long Stokes shift (ranged from 136 to 198 nanometers) and small molecular weight (<450 daltons). The most promising SOD9 shows rapid renal excretion and blood-brain barrier passing properties. After functioning with the mitochondrial-targeted triphenylphosphonium (TPP) group, the resulting SOD9-TPP can be engineered for head-neck tumor imaging, fluorescence image-guided surgery, brain neuroimaging, and on-site pathologic analysis. In summary, our findings add an essential small molecular dye category to the classical dyes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.