ArticleJNCI cancer spectrum2022
Body mass index trajectories, weight gain and risks of liver and biliary tract cancers.
Article in JNCI cancer spectrum, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
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Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 10 citations in OpenAlex.
- Life Course Trajectories of Body Mass Index and Risk of Cancer in Adulthood: Systematic Review and Meta-Analysis.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026Pooled it
- Role of body mass index and weight change in the risk of cancer: A systematic review and meta-analysis of 66 cohort studies.Journal of global health · 2024Pooled it
- Trajectory Modelling of Prognostic Biomarkers Linked to Liver Cancer Risk: A Systematic Review.Liver cancer · 2026Article
- Article
- Obesity and Cancer: Mechanisms, Epidemiological Evidence, and Potential Risk Reduction.Journal of obesity & metabolic syndrome · 2026Review
- Article
- Barriers and facilitators to prostate cancer healthcare in Black men in the UK: from diagnosis to survivorship.Journal of cancer survivorship : research and practice · 2025Article
- Life-long body mass index trajectories and cardiometabolic biomarkers-the Danish diet, cancer, and health-next generations cohort.International journal of obesity (2005) · 2025Article
- Variation by age, smoking, and menopausal status in the impact of body mass index change on liver cancer risk.Scientific reports · 2025Article
- Associations of body mass index and waist circumference with incidence of overall and of 27 site-specific cancers: a population-based retrospective cohort study.Cancer communications (London, England) · 2025Article
- Trajectories of body mass index and incident kidney stone disease: a prospective cohort study in Chinese young adults.Urolithiasis · 2024Article
- Obesity and Risk of Liver and Biliary Tract Cancer: Does Timing and Trajectory Matter?JNCI cancer spectrum · 2022Article
Corrections and comments
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Authors and funding
15 authors at 11 institutions in 2 countries.
Funding
Abstract
backgroundLittle is known about the role of early obesity or weight change during adulthood in the development of liver cancer and biliary tract cancer (BTC).
methodsWe investigated the associations of body mass index (BMI) and weight trajectories with the risk of liver cancer and BTC in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial (PLCO). BMI was self-reported at ages 20, 50, and at enrollment. BMI trajectories were determined using latent class growth models. Cox regression was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs).
resultsDuring a median follow-up of 15.9 years among 138,922 participants, 170 liver cancer and 143 BTC cases were identified. Compared with those whose BMI does not exceed 25 kg/m2, participants with BMI exceeding 25 kg/m2 at age 20 had increased risks of liver cancer (HR = 2.03, 95% CI: 1.26-3.28) and BTC (HR = 1.99, 95% CI: 1.16-3.39). Compared to participants maintaining normal BMI until enrollment, trajectory of normal weight at age 20 to obesity at enrollment was associated with increased risk for liver cancer (HR = 2.50, 95% CI: 1.55-4.04) and BTC (HR = 1.83, 95% CI: 1.03-3.22). Compared to adults with stable weight (+/-5kg) between age 20 to 50 years, weight gain ≥20 kg between ages 20 to 50 years had higher HRs of 2.24 (95%CI: 1.40-3.58) for liver cancer and 1.86 (95% CI: 1.12-3.09) for BTC.
conclusionsBeing overweight/obese at age 20, and BMI trajectories that result in being overweight and/or obese, may increase risk for both liver cancer and BTC.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.