Evidence map›Paper›PMID 35960510›Full record

ArticleBiochemistry2022

Hydroxylation Regiochemistry Is Robust to Active Site Mutations in Cytochrome P450

Guadalupe Alvarez, Thu Le, Nathan Wong, Julian Echave, Thomas C Pochapsky, Eliana K Asciutto

Open access · greenAbstract read
In one paragraph

Article in Biochemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Guadalupe AlvarezInstituto de Ciencias Físicas, Universidad Nacional de San Martín & CONICET, Campus Migueletes, 25 de Mayo y Francia, Buenos Aires 1650, Argentina.
Thu LeDepartment of Biochemistry, Brandeis University, 415 South Street, Waltham, Massachusetts 02454, United States.
Nathan WongDepartment of Biochemistry, Brandeis University, 415 South Street, Waltham, Massachusetts 02454, United States.ORCID 0000-0001-8178-1184
Julian EchaveInstituto de Ciencias Físicas, Universidad Nacional de San Martín & CONICET, Campus Migueletes, 25 de Mayo y Francia, Buenos Aires 1650, Argentina.
Thomas C PochapskyDepartment of Biochemistry, Brandeis University, 415 South Street, Waltham, Massachusetts 02454, United States.ORCID 0000-0001-8995-1088
Eliana K AsciuttoInstituto de Ciencias Físicas, Universidad Nacional de San Martín & CONICET, Campus Migueletes, 25 de Mayo y Francia, Buenos Aires 1650, Argentina.ORCID 0000-0002-8931-027X
Brandeis University · USConsejo Nacional de Investigaciones Científicas y Técnicas · AR

Funding

Macromolecular Structure MechanismT32GM007596 · NIGMS · BRANDEIS UNIVERSITY · PI OPRIAN, DANIEL D · 1985 to 2019
$4.5M
Structure and dynamics of clinically-relevant cytochrome P450 enzymes - Summer undergraduate research experience supplementR01GM130997 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI POCHAPSKY, THOMAS CHARLES, SCOTT, EMILY E · 2019 to 2022
$1.8M
NIGMS NIH HHS R01 GM130997NIGMS NIH HHS T32 GM007596
6 · The paper itself

Abstract

Cytochrome P450

Indexed as

CamphorCamphor 5-MonooxygenaseCatalytic DomainCytochrome P-450 Enzyme SystemHydroxylationMutationOxygenSubstrate SpecificityCamphorCamphor 5-MonooxygenaseCytochrome P-450 Enzyme SystemOxygen

Identifiers

PMID35960510
PMCPMC9721313
OpenAlexW4290831114

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.