Evidence map›Paper›PMID 35960493›Full record

ArticleHigh blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension2022

The Influence of ABCB1 (rs1045642 and rs4148738) Gene Polymorphisms on Rivaroxaban Pharmacokinetics in Patients Aged 80 Years and Older with Nonvalvular Atrial Fibrillation.

Dmitry Sychev, Olga Ostroumova, Marina Cherniaeva, Nataliia Shakhgildian, Karin Mirzaev, Sherzod Abdullaev, Natalia Denisenko, Zhannet Sozaeva, Anastasia Kachanova, Svetlana Gorbatenkova and 1 more

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In one paragraph

Article in High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Association ofFrontiers in cardiovascular medicine · 2026
    Article
  4. Review
  5. Review
  6. Article
  7. Observational
  8. Review
  9. Common P-glycoprotein (Biochemia medica · 2024
    Article
  10. Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Dmitry SychevDepartment of Clinical Pharmacology and Therapy, Russian Medical Academy of Continuous Professional Education, 2/1 Barrikadnaya St., Moscow, 123242, Russian Federation.ORCID http://orcid.org/0000-0002-4496-3680
Olga OstroumovaDepartment of Clinical Pharmacology and Therapy, Russian Medical Academy of Continuous Professional Education, 2/1 Barrikadnaya St., Moscow, 123242, Russian Federation.ORCID http://orcid.org/0000-0002-0795-8225
Marina CherniaevaDepartment of Internal and Preventive Medicine, Central State Medical Academy of the Presidential Administration of the Russian Federation, Marshal Timoshenko Street, 19, Building 1A, Moscow, 121359, Russian Federation. doctor@cherniaeva.ru.ORCID http://orcid.org/0000-0003-3091-7904
Nataliia ShakhgildianLomonosov Moscow State University Medical Research and Educational Center, 27\10, Lomonosovskiy Prospekt, Moscow, 119991, Russian Federation.ORCID http://orcid.org/0000-0002-7367-6461
Karin MirzaevDepartment of Clinical Pharmacology and Therapy, Russian Medical Academy of Continuous Professional Education, 2/1 Barrikadnaya St., Moscow, 123242, Russian Federation.ORCID http://orcid.org/0000-0002-9307-4994
Sherzod AbdullaevDepartment of Clinical Pharmacology and Therapy, Russian Medical Academy of Continuous Professional Education, 2/1 Barrikadnaya St., Moscow, 123242, Russian Federation.ORCID http://orcid.org/0000-0001-9001-1499
Natalia DenisenkoDepartment of Clinical Pharmacology and Therapy, Russian Medical Academy of Continuous Professional Education, 2/1 Barrikadnaya St., Moscow, 123242, Russian Federation.ORCID http://orcid.org/0000-0003-3278-5941
Zhannet SozaevaDepartment of Clinical Pharmacology and Therapy, Russian Medical Academy of Continuous Professional Education, 2/1 Barrikadnaya St., Moscow, 123242, Russian Federation.ORCID http://orcid.org/0000-0001-5166-7903
Anastasia KachanovaDepartment of Clinical Pharmacology and Therapy, Russian Medical Academy of Continuous Professional Education, 2/1 Barrikadnaya St., Moscow, 123242, Russian Federation.ORCID http://orcid.org/0000-0003-3194-4410
Svetlana GorbatenkovaState Budgetary Institution of Health "Hospital for War Veterans No. 2" of the Department of Health of Moscow, Volgogradskiy Prospekt, 168, Moscow, 109472, Russian Federation.
Vera ShastinaState Budgetary Institution of Health "Hospital for War Veterans No. 2" of the Department of Health of Moscow, Volgogradskiy Prospekt, 168, Moscow, 109472, Russian Federation.

Funding

Russian Science Foundation 22-15-0025
6 · The paper itself

Abstract

introductionABCB1 gene polymorphisms are associated with rivaroxaban distribution changes and adverse reactions but the data are controversial.

aimTo evaluate the influence of ABCB1 (rs1045642 and rs4148738) gene polymorphisms on rivaroxaban pharmacokinetics in patients aged 80 years and older with nonvalvular atrial fibrillation (NAF).

methods128 patients aged 80 years and older (median [Me] age 87.5 [83.0-90.0] years) with NAF were included. We performed ABCB1 (rs1045642 and rs4148738) genotyping, measured the trough steady-state plasma concentration (C

resultsCC genotype carriers had no differences in C

conclusionABCB1 (rs1045642 and rs4148738) polymorphisms didn't influence rivaroxaban pharmacokinetics in patients aged 80 years and older with NAF. TT carriers developed CRNMB more frequently compared with the CC rs1045642 and the CC and CT rs4148738 genotypes. The haplotype TT-TT haplotype was associated with a higher frequency of CRNMB.

Indexed as

ATP Binding Cassette Transporter, Subfamily BAtrial FibrillationRivaroxabanAged, 80 and overGenotypeHaplotypesHumansPolymorphism, Single NucleotideABCB1 protein, humanATP Binding Cassette Transporter, Subfamily BRivaroxabanABCB1 (rs1045642)ABCB1 (rs4148738)Elderly patientsNonvalvular atrial fibrillationPharmacogeneticsRivaroxaban

Identifiers

PMID35960493

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.