ArticleAnnals of surgical oncology2022
Short-Term Outcomes of Epidural Analgesia in Minimally Invasive Esophagectomy for Esophageal Cancer: Nationwide Inpatient Data Study in Japan.
Article in Annals of surgical oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 18 citations in OpenAlex.
- Vasoactive-inotropic score and major cardiovascular events in patients undergoing esophagectomy: a retrospective analysis of intravenous lidocaine and thoracic epidural anesthesia.BMC anesthesiology · 2026Article
- Short-term outcomes of robot-assisted versus conventional thoracoscopic esophagectomy: a nationwide inpatient database study in Japan.Esophagus : official journal of the Japan Esophageal Society · 2026Article
- Epidurals in esophagectomy: end of an era?Journal of thoracic disease · 2026Article
- Perioperative outcomes of esophagectomy after doublet versus docetaxel-based triplet neoadjuvant chemotherapy in older patients: A nationwide inpatient database study in Japan.Annals of gastroenterological surgery · 2025Article
- Epidural analgesia during esophagectomy and esophageal cancer prognosis: A population-based nationwide study in Finland.Acta anaesthesiologica Scandinavica · 2025Article
- [Epidural Analgesia in Minimally Invasive Esophagectomy: Evidence and Practice].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2025Review
- Essential updates 2022/2023: Recent advances in perioperative management of esophagectomy to improve operative outcomes.Annals of gastroenterological surgery · 2024Review
- Outcome research on esophagectomy analyzed using nationwide databases in Japan: evidences generated from real-world data.Esophagus : official journal of the Japan Esophageal Society · 2024Review
- No difference in the incidence of postoperative pulmonary complications between abdominal laparoscopy and laparotomy for minimally invasive thoracoscopic esophagectomy: a retrospective cohort study using a nationwide Japanese database.Esophagus : official journal of the Japan Esophageal Society · 2024Article
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13 authors at 5 institutions in 1 country.
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Abstract
backgroundStudies have shown that epidural analgesia (EDA) is associated with a decreased risk of pneumonia and anastomotic leakage after esophagectomy, and several guidelines strongly recommend EDA use after esophagectomy. However, the benefit of EDA use in minimally invasive esophagectomy (MIE) remains unclear.
objectiveThe aim of this retrospective study was to compare the short-term outcomes between patients with and without EDA undergoing MIE for esophageal cancer.
methodsData of patients who underwent oncologic MIE (April 2014-March 2019) were extracted from a Japanese nationwide inpatient database. Stabilized inverse probability of treatment weighting (IPTW), propensity score matching, and instrumental variable analyses were performed to investigate the associations between EDA use and short-term outcomes, adjusting for potential confounders.
resultsAmong 12,688 eligible patients, EDA was used in 9954 (78.5%) patients. In-hospital mortality, respiratory complications, and anastomotic leakage occurred in 230 (1.8%), 2139 (16.9%), and 1557 (12.3%) patients, respectively. In stabilized IPTW, EDA use was significantly associated with decreased in-hospital mortality (odds ratio [OR] 0.46 [95% confidence interval 0.34-0.61]), respiratory complications (OR 0.74 [0.66-0.84]), and anastomotic leakage (OR 0.77 [0.67-0.88]). EDA use was also associated with decreased prolonged mechanical ventilation, unplanned intubation, nonsteroidal anti-inflammatory drug use, acetaminophen use, postoperative length of stay, and total hospitalization costs and increased vasopressor use. One-to-three propensity score matching and instrumental variable analyses demonstrated equivalent results.
conclusionsEDA use in oncologic MIE was associated with low in-hospital mortality as well as decreased respiratory complications, and anastomotic leakage, suggesting the potential advantage of EDA use in MIE.
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