Evidence map›Paper›PMID 35960452›Full record

ArticleAnnals of surgical oncology2022

Clinicopathologic Features, Treatment Patterns, and Disease Outcomes in a Modern, Prospective Cohort of Young Women Diagnosed with Ductal Carcinoma In Situ.

Megan E Tesch, Shoshana M Rosenberg, Laura C Collins, Julia S Wong, Laura Dominici, Kathryn J Ruddy, Rulla Tamimi, Lidia Schapira, Virginia F Borges, Ellen Warner and 2 more

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in Annals of surgical oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01468246 (Helping Ourselves, Helping Others), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01468246 active not recruitingnot on this map

Helping Ourselves, Helping Others: The Young Women's Breast Cancer Study

TypeobservationalSponsorDana-Farber Cancer InstituteRan2006 to 2035Enrolled1,302ConditionsBreast Cancer
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 9 institutions in 2 countries.

Megan E TeschDana-Farber Cancer Institute, Boston, MA, USA.
Shoshana M RosenbergWeill Cornell Medicine, New York, NY, USA.
Laura C CollinsBeth Israel Deaconess, Boston, MA, USA.
Julia S WongDana-Farber Cancer Institute, Boston, MA, USA.
Laura DominiciDana-Farber Cancer Institute, Boston, MA, USA.
Kathryn J RuddyMayo Clinic, Rochester, MN, USA.
Rulla TamimiWeill Cornell Medicine, New York, NY, USA.
Lidia SchapiraStanford University, Stanford, CA, USA.
Virginia F BorgesUniversity of Colorado Cancer Center, Denver, CO, USA.
Ellen WarnerSunnybrook Health Sciences Centre, Toronto, ON, Canada.
Steven E ComeBeth Israel Deaconess, Boston, MA, USA.
Ann H PartridgeDana-Farber Cancer Institute, Boston, MA, USA. ann_partridge@dfci.harvard.edu.
Harvard University · USDana-Farber Cancer Institute · USBrigham and Women's Hospital · USCancer Prevention Institute of California · USCornell University · USHealth Sciences Centre · CAMayo Clinic in Arizona · USUniversity of Colorado Denver · USWeill Cornell Medicine · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDuctal carcinoma in situ (DCIS) is uncommon and understudied in young women. The objective of this study is to describe clinicopathologic features, treatment, and oncologic outcomes in a modern cohort of women aged ≤ 40 years with DCIS. PATIENTS AND

methodsPatients with DCIS were identified from the Young Women's Breast Cancer Study, a multisite prospective cohort of women diagnosed with stage 0-IV breast cancer at age ≤ 40 years, enrolled from 2006 to 2016. Clinical data were collected from patient surveys and medical records. Pathologic features were examined by central review. Data were summarized with descriptive statistics and groups were compared with χ

resultsAmong the 98 patients included, median age of diagnosis was 38 years; 36 (37%) patients were symptomatic on presentation. DCIS nuclear grade was high in 35%, intermediate in 50%, and low in 15% of lesions; 36% of lesions had comedonecrosis. The majority of patients underwent bilateral mastectomy (57%), 16 (16%) underwent unilateral mastectomy, and 26 (27%) underwent lumpectomy, most of whom received radiation. Few (13%) patients were receiving tamoxifen therapy 1 year postdiagnosis. Over a median follow-up of 8.4 years, six patients (6%) had disease recurrence, including five locoregional and one distant event.

conclusionsA high proportion of young women with DCIS underwent mastectomy with or without contralateral prophylactic mastectomy. Although DCIS was frequently symptomatic on presentation and exhibited unfavorable pathologic factors, clinicopathologic features were overall heterogeneous and few recurrences occurred. This underscores the need for careful consideration of treatment options in young women with DCIS.

Indexed as

Breast NeoplasmsCarcinoma in SituCarcinoma, Intraductal, NoninfiltratingAdultFemaleHumansMastectomyMastectomy, SegmentalNeoplasm Recurrence, LocalProspective Studies

Identifiers

PMID35960452
OpenAlexW4290839513

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.