Evidence map›Paper›PMID 35960383›Full record

ArticleArchives of osteoporosis2022

Association between prior cancer diagnosis and osteoporosis: a matched case-control study.

Shuman Yang, Na Wang, Jianmeng Wang, Lisa M Lix, William D Leslie, Baoming Yuan

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Article in Archives of osteoporosis, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. A multicenter prospective matched comparative study on osteoporosis risk in cancer patients receiving chemotherapy.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Shuman YangDepartment of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, Jilin, China.
Na WangDepartment of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, Jilin, China.
Jianmeng WangDepartment of Geriatrics, The First Hospital of Jilin University, Changchun, Jilin, China.
Lisa M LixDepartment of Community Health Sciences, University of Manitoba, Winnipeg, MB, Canada.
William D LeslieDepartment of Internal Medicine, University of Manitoba, Winnipeg, MB, Canada.
Baoming YuanDepartment of Orthopaedics, The Second Hospital of Jilin University, 218 Ziqiang Street, Changchun, 130000, Jilin, China. yuanbm@jlu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Epidemiological studies show an inconsistent association between cancer and osteoporosis. In this nationally representative population-based study, we found that a prior cancer diagnosis was not associated with osteoporosis. This finding may primarily apply to cancer survivors seen many years after their cancer diagnosis.

backgroundEpidemiological studies show an inconsistent association between cancer and osteoporosis. We examined the association between a prior cancer diagnosis and osteoporosis in population-based data.

methodsWe performed an age- and sex-matched case-control study (1:2 matching ratio) using the National Health and Nutrition Examination Survey, 2011-2018. Cases were determined by self-reported prior diagnosis of cancer; all controls were free of cancer at the time of bone density measurement with dual-energy x-ray absorptiometry. We defined osteoporosis as a T-score ≤  - 2.5 at femoral neck, total hip, or lumbar spine. Unconditional multivariable logistic regression was used to test the association between a prior cancer diagnosis and osteoporosis.

resultsWe identified 246 prior cancer cases and 492 controls (mean age: 65.8 years) in females, and 243 prior cancer cases and 486 controls (mean age: 68.0 years) in males. The most common types of cancer in females and males were breast cancer and prostate cancer, respectively. Osteoporosis prevalences were comparable between cases and controls among females (19.1% in cases vs. 18.7% in controls; P = 0.894) and males (5.8% in cases vs. 6.8% in controls; P = 0.594). After adjusting for covariates, a prior cancer diagnosis was not associated with osteoporosis in females (odds ratio [OR]: 0.83; 95% confidence interval [CI]: 0.54-1.29) or males (OR: 1.09; 95% CI: 0.51-2.30). Results were unaffected by cancer severity, cancer type, or time since cancer diagnosis.

conclusionsA prior cancer diagnosis was not associated with osteoporosis in this nationally representative population.

Indexed as

NeoplasmsOsteoporosisAbsorptiometry, PhotonAgedBone DensityCase-Control StudiesFemaleFemur NeckHumansLumbar VertebraeMaleNutrition SurveysBone mineral densityCancerOsteoporosisRisk assessment

Identifiers

PMID35960383

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.