ArticleACS applied materials & interfaces2022
Antibacterial Properties and Mechanisms of Action of Sonoenzymatically Synthesized Lignin-Based Nanoparticles.
Article in ACS applied materials & interfaces, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 109 citations in OpenAlex.
- Advancing polyallophanate powder coating performance and function with colloidal lignin particles.RSC advances · 2026Article
- Gallate-oriented surface engineering of lignin nanoparticles for enhanced antibacterial activity.Materials today. Bio · 2026Article
- Lignin-Based Fluorescent Polymers: From Aggregation-Induced Emission Mechanism to Intelligent Bone Regeneration.Macromolecular bioscience · 2026Review
- Molecular Insights into Lignin Bioactivity: From Structural Architecture to Sustainable Food Industry Applications.International journal of molecular sciences · 2026Review
- Harnessing the Antimicrobial Potential of Baicalein-Coated FeACS applied materials & interfaces · 2026Article
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- Compost Tea as a Natural Bioactive Solution: Unlocking the Antimicrobial and Antiviral Potential of Bell Pepper and Citrus Wastes.Environmental microbiology reports · 2026Article
- Lignin Nanoparticles Containing Cobalt-Cyanine Complexes: Potential Multifunctional Platforms for Photoacoustic Imaging and Photothermal Treatment of Bacterial Biofilms in Chronic Wounds.Macromolecular bioscience · 2026Article
- Solvent-Free One-Pot Preparation of Lignin-Ferric Nanoparticles for Enhanced Antibacterial Therapy.Drug design, development and therapy · 2026Article
- Alkali Lignin-Based Biopolymer Formulations for Electro-Assisted Drug Delivery of Natural Antioxidants in Breast Cancer Cells-A Preliminary Study.International journal of molecular sciences · 2025Article
- Innovative In Situ Interfacial Co-Assembled Lignin/Chitosan Nanoparticles-Green Synthesis, Physicochemical Characterization, In Vitro Release, and Intermolecular Interactions.International journal of molecular sciences · 2025Article
- Lignin and Nanolignin: Next-Generation Sustainable Materials for Water Treatment.ACS applied bio materials · 2025Review
- Adverse Outcome Pathways (AOPs) Oriented Approach to Assess In Vitro Hazard of Silica and Lignin Nanomaterials Derived from Biomass Residues.Nanomaterials (Basel, Switzerland) · 2025Article
- Unlocking lignin valorization and harnessing lignin-based raw materials for bio-manufacturing.Science China. Life sciences · 2025Review
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- Antimicrobial Sponge: A Polyvinyl Alcohol, Tannic Acid and Curcumin-Loaded Nanolignin Hydrogel Composite Scaffold.Gels (Basel, Switzerland) · 2025Article
- Lignin-Based Mucus-Mimicking Antiviral Hydrogels with Enzyme Stability and Tunable Porosity.ACS applied materials & interfaces · 2025Article
- Biobased Organic Nanoparticles: A Promising Versatile Green Tool for Novel Antimicrobial Agents for Improved Safety.International journal of food science · 2025Review
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Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In recent years, lignin has drawn increasing attention for different applications due to its intrinsic antibacterial and antioxidant properties, coupled with biodegradability and biocompatibility. However, chemical modification or combination with metals is usually required to increase its antimicrobial functionality and produce biobased added-value materials for applications wherein bacterial growth should be avoided, such as biomedical and food industries. In this work, a sonoenzymatic approach for the simultaneous functionalization and nanotransformation of lignin to prepare metal-free antibacterial phenolated lignin nanoparticles (PheLigNPs) is developed. The grafting of tannic acid, a natural phenolic compound, onto lignin was achieved by an environmentally friendly approach using laccase oxidation upon the application of high-intensity ultrasound to rearrange lignin into NPs. PheLigNPs presented higher antibacterial activity than nonfunctionalized LigNPs and phenolated lignin in the bulk form, indicating the contribution of both the phenolic content and the nanosize to the antibacterial activity. Studies on the antibacterial mode of action showed that bacteria in contact with the functionalized NPs presented decreased metabolic activity and high levels of reactive oxygen species (ROS). Moreover, PheLigNPs demonstrated affinity to the bacterial surface and the ability to cause membrane destabilization. Antimicrobial resistance studies showed that the NPs did not induce resistance in pathogenic bacteria, unlike traditional antibiotics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.