ArticleThe Plant cell2022
A gain-of-function allele of a DREB transcription factor gene ameliorates drought tolerance in wheat.
Article in The Plant cell, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
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Who cites it
59 citing papers in PubMed, 154 citations in OpenAlex.
- Review
- Improving Nitrogen Use Efficiency in Wheat: Integrating Agronomic, Genomics, and Remote Sensing for Sustainable Production.Plant, cell & environment · 2026Review
- A natural allele of TaSCE1-A1 confers drought resistance in wheat.Nature plants · 2026Article
- Genome-wide analysis of Ariadne genes associated with drought and salt stress tolerance in wheat (Triticum aestivum L.).BMC plant biology · 2026Article
- Crops exposed to extreme conditions: perspectives of gene editing to improve stress tolerance.Plant cell reports · 2026Review
- Comprehensive analysis of HB-PHD transcription factors associated with drought and salt stresses in wheat.BMC genomics · 2026Article
- Advances in gene cloning and functional genomics approaches for wheat (Triticum aestivum L.) improvement.The plant genome · 2026Review
- Plant Genetic Engineering: Technological Pathways, Application Scenarios, and Future Directions.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Tomato NAC2-DREB2 module fine-tunes saline-alkali stress sensitivity via modulation of melatonin biosynthesis and ROS homeostasis.Horticulture research · 2026Article
- Cloning and Characterization ofPlants (Basel, Switzerland) · 2026Article
- Genome-wide analysis of the AP2 transcription factor family in cultivated sugarcane reveals ShAP2-1 as an enhancer of drought tolerance.BMC plant biology · 2026Article
- The Floral Bottleneck in a Changing Climate: Molecular Mechanisms, Knowledge Gaps, and Future Directions.International journal of molecular sciences · 2026Review
- Genomics in wheat improvement: Progress and perspectives.The plant genome · 2026Review
- MsDREB2A modulates alfalfa growth by regulating MsCRE1 involved in cytokinin biosynthesis.BMC plant biology · 2026Article
- Genome-wide analysis of the DREB gene family and functional characterization of HaDREB1D in the drought stress response in sunflower (Helianthus annuus L.).BMC genomics · 2026Article
- Physiological and Transcriptomic Analysis of Bread Wheat MicroRNAs in Response to Zinc Availability.Biomolecules · 2026Article
- Comprehensive analysis of ABA-aldehyde oxidase genes associated with drought and salt stress tolerance in wheat (Frontiers in plant science · 2026Article
- Genome-wide identification and expression patterns analysis of the DREB gene family under various abiotic stress in Lolium perenne.BMC plant biology · 2025Article
- Manipulation of the Expression of Tryptophan Decarboxylase Boosts Grain Functional Quality and Stress Resilience Capacity of Wheat.Plant biotechnology journal · 2025Article
- Characterization of DREB family genes in loquat and their co-expression network analysis in response to drought.BMC plant biology · 2025Article
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Drought is a major environmental factor limiting wheat production worldwide. However, the genetic components underlying wheat drought tolerance are largely unknown. Here, we identify a DREB transcription factor gene (TaDTG6-B) by genome-wide association study that is tightly associated with drought tolerance in wheat. Candidate gene association analysis revealed that a 26-bp deletion in the TaDTG6-B coding region induces a gain-of-function for TaDTG6-BDel574, which exhibits stronger transcriptional activation, protein interactions, and binding activity to dehydration-responsive elements (DRE)/CRT cis-elements than the TaDTG6-BIn574 encoded by the allele lacking the deletion, thus conferring greater drought tolerance in wheat seedlings harboring this variant. Knockdown of TaDTG6-BDel574 transcripts attenuated drought tolerance in transgenic wheat, whereas its overexpression resulted in enhanced drought tolerance without accompanying phenotypic abnormalities. Furthermore, the introgression of the TaDTG6-BDel574 elite allele into drought-sensitive cultivars improved their drought tolerance, thus providing a valuable genetic resource for wheat breeding. We also identified 268 putative target genes that are directly bound and transcriptionally regulated by TaDTG6-BDel574. Further analysis showed that TaDTG6-BDel574 positively regulates TaPIF1 transcription to enhance wheat drought tolerance. These results describe the genetic basis and accompanying mechanism driving phenotypic variation in wheat drought tolerance, and provide a novel genetic resource for crop breeding programs.
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