ArticleEuropean journal of pain (London, England)2022
Chronic postoperative pain after total knee arthroplasty: The potential contributions of synovitis, pain sensitization and pain catastrophizing-An explorative study.
Article in European journal of pain (London, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07736248 (Super Selective Angiographic Catheterization and Embolization of Genicular Arteries for Treatment of Symptomatic Knee Osteoarthritis), which is not on this map. Cited by 32 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Super Selective Angiographic Catheterization and Embolization of Genicular Arteries for Treatment of Symptomatic Knee Osteoarthritis
Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Are preoperative psychological factors associated with chronic postoperative pain after total knee arthroplasty: a systematic review.EFORT open reviews · 2026Pooled it
- Peripheral nerve stimulation for chronic knee pain following total knee arthroplasty: a systematic review.Pain management · 2023Pooled it
- The analgesic effect of continuous adductor canal block combined with popliteal plexus block for total knee arthroplasty: a randomized controlled trial.Scientific reports · 2024Trial
- Femoral nerve block using lower concentration ropivacaine preserves quadriceps strength while providing similar analgesic effects after knee arthroscopy.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2023Trial
- Effects of pain neuroscience education combined with blood flow restriction training on chronic postoperative pain following total knee arthroplasty: a randomized controlled trial protocol.Journal of orthopaedic surgery and research · 2026Article
- The complexity of pain in osteoarthritis.Nature reviews. Rheumatology · 2026Review
- Visual Hypersensitivity as a Transdiagnostic Marker of Surgical Pain Response in Arthritis and Chronic Pain Syndromes.Arthritis & rheumatology (Hoboken, N.J.) · 2026Article
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- Personalizing the Management of Knee Osteoarthritis.SMART-MD journal of precision medicine · 2026Article
- Early Postoperative Pain and Its Risk Factors in Patients Undergoing Total Knee Arthroplasty Under the ERAS Protocol.Journal of pain research · 2026Article
- Inflammatory phenotypes after total knee arthroplasty: a testable framework for biomarker-stratified enhanced recovery and precision rehabilitation.Frontiers in medicine · 2026Article
- Multifactorial Machine Learning Algorithm Integration of Pain Mechanisms Can Predict the Efficacy of 3-Week NSAID Plus Paracetamol in Patients With Painful Knee Osteoarthritis.European journal of pain (London, England) · 2025Article
- Examining the thoughts and experiences of repeatedly revised knee arthroplasty patients-a qualitative study.BMC musculoskeletal disorders · 2025Article
- Passive Blood-Flow-Restriction Exercise's Impact on Muscle Atrophy Post-Total Knee Replacement: A Randomized Trial.Journal of clinical medicine · 2025Article
- Catastrophizing and fear avoidance beliefs in chronic low back pain: a cross-sectional study.European journal of physical and rehabilitation medicine · 2025Article
- Comparative analysis of the parapatellar and subpatellar approaches in reducing peripheral knee pain post-intramedullary tibial fracture surgery.BMC surgery · 2025Article
- Mitochondrial transplantation: a promising strategy for treating degenerative joint diseases.Journal of translational medicine · 2024Review
- Arthroscopic Debridement After Total Knee Arthroplasty Is More Effective for Synovitis Than for Ankylosis.Arthroscopy, sports medicine, and rehabilitation · 2024Article
- A single-center retrospective chart review of percutaneous PNS for treatment of chronic shoulder pain.Interventional pain medicine · 2024Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundA subset of osteoarthritis patients will experience chronic postoperative pain after total knee arthroplasty (TKA), but the source of pain is unclear. The aim of this exploratory study was to assess patients with and without postoperative pain after TKA using magnetic resonance imaging (MRI), quantitative sensory testing (QST), clinical assessment of pain and assessments of catastrophizing thoughts.
methodsForty-six patients completed the 6-month postoperative assessment. MRI findings were scored according to the MRI Osteoarthritis Knee Score recommendation for Hoffa synovitis, effusion size and bone marrow lesions. QST included assessment of pressure pain thresholds (PPTs), temporal summation of pain (TSP) and conditioned pain modulation (CPM). Pain catastrophizing was assessed using the Pain Catastrophizing Scale (PCS). Clinical pain assessment was conducted using a visual analogue scale (VAS, 0-10 cm), and groups of moderate-to-severe (VAS > 3) and none-to-mild postoperative pain (VAS ≤ 3) were identified.
resultsPatients with moderate-to-severe postoperative pain (N = 15) demonstrated higher grades of Hoffa synovitis (p < 0.001) and effusion size (p < 0.001), lower PPTs (p = 0.039), higher TSP (p = 0.001) and lower CPM (p = 0.014) when compared with patients with none-to-mild postoperative pain (N = 31). No significant difference was found in PCS scores between the two groups. Multiple linear regression models found synovitis (p = 0.036), effusion size (p = 0.003), TSP (p = 0.013) and PCS (p < 0.001) as independent parameters contributing to the postoperative pain intensity.
conclusionThese exploratory findings could indicate that chronic postoperative pain after TKA is a combination of joint-related synovitis and effusion, sensitization of central pain mechanisms and potentially pain catastrophizing thoughts, but larger studies are needed to confirm this. SIGNIFICANCE: The end-stage treatment of knee osteoarthritis is total knee arthroplasty. Some patients experience chronic postoperative pain after total knee arthroplasty, but the mechanism for chronic postoperative pain is widely unknown. The current study indicates that higher levels postoperative of synovitis and effusion, higher temporal summation of pain and higher pain catastrophizing scores could be associated with higher chronic postoperative pain.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.