Evidence map›Paper›PMID 35959677›Full record

ArticleCirculation. Cardiovascular quality and outcomes2022

Indications for Left Atrial Appendage Occlusion in the United States and Associated In-Hospital Outcomes: Results From the NCDR LAAO Registry.

Usama A Daimee, Yongfei Wang, Frederick A Masoudi, Paul D Varosy, Daniel J Friedman, Chengan Du, Cristina Koutras, Vivek Y Reddy, Jacqueline Saw, Matthew J Price and 3 more

Open access · greenAbstract read
In one paragraph

Article in Circulation. Cardiovascular quality and outcomes, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Left Atrial Appendage Occlusion Device-Associated Infective Endocarditis: Analysis of the FDA-MAUDE Database.Journal of the Society for Cardiovascular Angiography & Interventions · 2026
    Article
  3. Percutaneous left atrial appendage closure for stroke prevention: current challenges and future perspectives.Clinical research in cardiology : official journal of the German Cardiac Society · 2026
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Left Atrial Appendage Occlusion: Expanding Indications and New Developments.Structural heart : the journal of the Heart Team · 2025
    Review
  10. Article
  11. Article
  12. In-hospital safety outcomes of left atrial appendage occlusion in octogenarians and nonagenarians.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2024
    Article
  13. Article
  14. Review
  15. Article
  16. Transcatheter Left Atrial Appendage Closure.Methodist DeBakey cardiovascular journal · 2023
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 9 institutions in 2 countries.

Usama A DaimeeDivision of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD (U.A.D.).ORCID 0000-0002-2839-5564
Yongfei WangCenter for Outcomes Research and Evaluation Yale New Haven Health Services Corporation, New Haven, CT (Y.W., D.J.F., C.D., J.P.C., J.V.F.).ORCID 0000-0001-5764-2213
Frederick A MasoudiDivision of Cardiology, University of Colorado Anschutz Medical Campus, Aurora (F.A.M., P.D.V.).ORCID 0000-0002-5681-6709
Paul D VarosyDivision of Cardiology, University of Colorado Anschutz Medical Campus, Aurora (F.A.M., P.D.V.).
Daniel J FriedmanCenter for Outcomes Research and Evaluation Yale New Haven Health Services Corporation, New Haven, CT (Y.W., D.J.F., C.D., J.P.C., J.V.F.).
Chengan DuCenter for Outcomes Research and Evaluation Yale New Haven Health Services Corporation, New Haven, CT (Y.W., D.J.F., C.D., J.P.C., J.V.F.).
Cristina KoutrasAmerican College of Cardiology Foundation, Washington, DC (C.K.).
Vivek Y ReddyDivision of Cardiology, Icahn School of Medicine at Mount Sinai, New York, NY (V.Y.R.).ORCID 0000-0002-5638-4993
Jacqueline SawDivision of Cardiology, Vancouver General Hospital, The University of British Columbia (J.S.).ORCID 0000-0002-7027-984X
Matthew J PriceDivision of Cardiovascular Diseases, Scripps Clinic, La Jolla, CA (M.J.P.).ORCID 0000-0002-7892-2430
Fred M KusumotoDepartment of Cardiovascular Disease, Mayo Clinic, Jacksonville, FL (F.M.K.).ORCID 0000-0002-8300-6277
Jeptha P CurtisCenter for Outcomes Research and Evaluation Yale New Haven Health Services Corporation, New Haven, CT (Y.W., D.J.F., C.D., J.P.C., J.V.F.).ORCID 0000-0002-6872-0501
James V FreemanCenter for Outcomes Research and Evaluation Yale New Haven Health Services Corporation, New Haven, CT (Y.W., D.J.F., C.D., J.P.C., J.V.F.).ORCID 0000-0002-4614-6879
Yale University · USUniversity of Colorado Anschutz Medical Campus · USYale New Haven Health System · USAmerican College of Cardiology · USIcahn School of Medicine at Mount Sinai · USJacksonville College · USJohns Hopkins University · USScripps Clinic · USVancouver General Hospital · CA

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Safety and Effectiveness of Left Atrial Appendage Closure in Atrial Fibrillation (SAFELY-AF)R01HL142765 · NHLBI · YALE UNIVERSITY · PI FREEMAN, JAMES · 2019 to 2022
$2.9M
Safety and Effectiveness of Left Atrial Appendage Closure in Atrial Fibrillation (SAFELY-AF)R56HL142765 · NHLBI · YALE UNIVERSITY · PI FREEMAN, JAMES · 2018 to 2018
$657k
NCATS NIH HHS UL1 TR001863NHLBI NIH HHS R01 HL142765NHLBI NIH HHS R56 HL142765
6 · The paper itself

Abstract

backgroundThe Food and Drug Administration approved left atrial appendage occlusion with the Watchman device for patients who are at increased stroke risk and are suitable for oral anticoagulation but who have an appropriate reason to seek a nondrug alternative. These broad criteria raise the question of their interpretation in clinical practice. There is a lack of studies comprehensively evaluating the indications for Watchman implantation among a large series of patients from contemporary, real-world practice in the United States.

methodsWe used the National Cardiovascular Data Registry Left Atrial Appendage Occlusion Registry to identify Watchman procedures performed between 2016 and 2018. We assessed procedural indications for Watchman implantation in the United States and evaluated the association between procedural indications and in-hospital adverse events.

resultsA total of 38 314 procedures were included. The mean patient age was 76.1±8.1 years, and 58.9% were men. The mean CHA

conclusionsAmong patients in the National Cardiovascular Data Registry Left Atrial Appendage Occlusion Registry, the most common procedural indications for Watchman implantation were increased thromboembolic risk, history of major bleed, and high fall risk. A majority of patients had multiple procedural indications. High fall risk conferred a modestly increased risk of in-hospital adverse events.

Indexed as

Atrial AppendageAtrial FibrillationStrokeThromboembolismAgedAged, 80 and overFemaleGastrointestinal HemorrhageHospitalsHumansMaleRegistriesTreatment OutcomeUnited StatesanticoagulantshospitalshumansregistriesUnited States

Identifiers

PMID35959677
PMCPMC9388561
OpenAlexW4291144691

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.