Evidence map›Paper›PMID 35959517›Full record

ArticleAPMIS : acta pathologica, microbiologica, et immunologica Scandinavica2022

Total fecal IgA levels increase and natural IgM antibodies decrease after gastric bypass surgery.

Natalie Istomin, Mari-Anne Härma, Ramin Akhi, Antti E Nissinen, Markku J Savolainen, Krishna Adeshara, Markku Lehto, Per-Henrik Groop, Vesa Koivukangas, Janne Hukkanen and 1 more

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In one paragraph

Article in APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Natalie IstominMedical Microbiology and Immunology, Research Unit of Biomedicine, University of Oulu, Oulu, Finland.ORCID https://orcid.org/0000-0003-2023-9484
Mari-Anne HärmaFolkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland.
Ramin AkhiMedical Microbiology and Immunology, Research Unit of Biomedicine, University of Oulu, Oulu, Finland.
Antti E NissinenMedical Microbiology and Immunology, Research Unit of Biomedicine, University of Oulu, Oulu, Finland.
Markku J SavolainenMedical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland.
Krishna AdesharaFolkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland.
Markku LehtoFolkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland.
Per-Henrik GroopFolkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland.
Vesa KoivukangasMedical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland.
Janne HukkanenMedical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland.
Sohvi HörkköMedical Microbiology and Immunology, Research Unit of Biomedicine, University of Oulu, Oulu, Finland.
Oulu University Hospital · FIUniversity of Helsinki · FI

Funding

Academy of Finland 275614Academy of Finland 315568Academy of Finland 316664Diabetes Research FoundationFinnish Foundation for Cardiovascular ResearchFinnish Medical FoundationFolkhälsan Research FoundationHelsinki University Central HospitalNorthern Finland Health Care Support FoundationNovo Nordisk Foundation (#NNF OC0013659Päivikki and Sakari Sohlberg FoundationSigne and Ane Gyllenberg FoundationWilhelm and Else Stockmann FoundationYrjö Jahnsson Foundation 20197174
6 · The paper itself

Abstract

Obesity is associated with low-grade inflammation and increased systemic oxidative stress. Roux-en-Y gastric bypass (RYGB) surgery is known to ameliorate the obesity-induced metabolic dysfunctions. We aimed to study the levels of natural antibodies in feces, before and 6 months after RYGB surgery in obese individuals with and without type 2 diabetes (T2D). Sixteen individuals with T2D and 14 non-diabetic (ND) individuals were operated. Total IgA, IgG and IgM antibody levels and specific antibodies to oxidized low-density lipoprotein (oxLDL), malondialdehyde-acetaldehyde adducts (MAA adducts), Porphyromonas gingivalis gingipain A hemagglutinin domain (Rgp44) and phosphocholine (PCho) were measured using chemiluminescence immunoassay. Total fecal IgA was elevated, while total IgM and IgG were not affected by the surgery. Fecal natural IgM specific to oxLDL decreased significantly in both T2D and ND individuals, while fecal IgM to Rgp44 and PCho decreased significantly in T2D individuals. A decrease in IgG to MAA-LDL, Rgp44 and PCho was detected. RYGB surgery increases the levels of total fecal IgA and decreases fecal natural IgG and IgM antibodies specific to oxLDL. Natural antibodies and IgA are important in maintaining the normal gut homeostasis and first-line defense against microbes, and their production is markedly altered with RYGB surgery.

Indexed as

Diabetes Mellitus, Type 2Gastric BypassAcetaldehydeFecesGingipain Cysteine EndopeptidasesHemagglutininsHumansImmunoglobulin AImmunoglobulin GImmunoglobulin MLipoproteins, LDLMalondialdehydeObesityPhosphorylcholineAcetaldehydeGingipain Cysteine EndopeptidasesHemagglutininsImmunoglobulin AImmunoglobulin GImmunoglobulin MLipoproteins, LDLMalondialdehydePhosphorylcholineimmunoglobulinsnatural antibodiesobesityRoux-en-Y gastric bypass surgerytype 2 diabetes

Identifiers

PMID35959517
PMCPMC9805076
OpenAlexW4291156843

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.