Evidence map›Paper›PMID 35959489›Full record

ReviewFrontiers in cell and developmental biology2022

Exosomes in osteoarthritis: Updated insights on pathogenesis, diagnosis, and treatment.

Wen-Jin Fan, Di Liu, Lin-Yuan Pan, Wei-Yang Wang, Yi-Lan Ding, Yue-Yao Zhang, Rui-Xi Ye, Yang Zhou, Sen-Bo An, Wen-Feng Xiao

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in cell and developmental biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 1 pooled it
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.

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  12. [Mechanisms of Exosomes in Lung Cancer Bone Metastasis and Related Clinical Advances].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Wen-Jin FanXiangya School of Medicine, Central South University, Changsha, China.
Di LiuDepartment of Orthopedics, Xiangya Hospital, Central South University, Changsha, China.
Lin-Yuan PanDepartment of Orthopedics, Xiangya Hospital, Central South University, Changsha, China.
Wei-Yang WangXiangya School of Medicine, Central South University, Changsha, China.
Yi-Lan DingXiangya School of Medicine, Central South University, Changsha, China.
Yue-Yao ZhangXiangya School of Medicine, Central South University, Changsha, China.
Rui-Xi YeXiangya School of Medicine, Central South University, Changsha, China.
Yang ZhouDepartment of Clinical Nursing, Xiangya Hospital, Central South University, Changsha, China.
Sen-Bo AnDepartment of Orthopaedics, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.
Wen-Feng XiaoDepartment of Orthopedics, Xiangya Hospital, Central South University, Changsha, China.
Central South University · CNXiangya Hospital Central South University · CNShandong First Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Osteoarthritis (OA) has remained a prevalent public health problem worldwide over the past decades. OA is a global challenge because its specific pathogenesis is unclear, and no effective disease-modifying drugs are currently available. Exosomes are small and single-membrane vesicles secreted via the formation of endocytic vesicles and multivesicular bodies (MVBs), which are eventually released when MVBs fuse with the plasma membrane. Exosomes contain various integral surface proteins derived from cells, intercellular proteins, DNAs, RNAs, amino acids, and metabolites. By transferring complex constituents and promoting macrophages to generate chemokines and proinflammatory cytokines, exosomes function in pathophysiological processes in OA, including local inflammation, cartilage calcification and degradation of osteoarthritic joints. Exosomes are also detected in synovial fluid and plasma, and their levels continuously change with OA progression. Thus, exosomes, specifically exosomal miRNAs and lncRNAs, potentially represent multicomponent diagnostic biomarkers for OA. Exosomes derived from various types of mesenchymal stem cells and other cell or tissue types affect angiogenesis, inflammation, and bone remodeling. These exosomes exhibit promising capabilities to restore OA cartilage, attenuate inflammation, and balance cartilage matrix formation and degradation, thus demonstrating therapeutic potential in OA. In combination with biocompatible and highly adhesive materials, such as hydrogels and cryogels, exosomes may facilitate cartilage tissue engineering therapies for OA. Based on numerous recent studies, we summarized the latent mechanisms and clinical value of exosomes in OA in this review.

Indexed as

biomarkerscartilagecartilage tissue engineeringexosomesosteoarthritis

Identifiers

PMID35959489
PMCPMC9362859
OpenAlexW4287921758

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.