ArticleFrontiers in neurology2022
Longitudinal ventricular cerebrospinal fluid profile in patients with spontaneous subarachnoid hemorrhage.
Article in Frontiers in neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Regulatory T Cell- and Natural Killer Cell-Mediated Inflammation, Cerebral Vasospasm, and Delayed Cerebral Ischemia in Aneurysmal Subarachnoid Hemorrhage-A Systematic Review and Meta-Analysis Approach.International journal of molecular sciences · 2025Pooled it
- Machine Learning-Based Prediction of Delayed Cerebral Ischemia and Functional Outcome in Aneurysmal Subarachnoid Hemorrhage: The Role of CNS Infection-Related Parameters.Biomedicines · 2026Article
- Association of Serial Ventricular Routine Cerebrospinal Fluid Findings with Complications and Outcome in Aneurysmal Subarachnoid Hemorrhage: A Retrospective Observational Study.Neurocritical care · 2026Observational
- Automated Cell Counting in CSF Diagnostics Revisited-Friend or Foe?Diagnostics (Basel, Switzerland) · 2025Article
- The Feasibility of Early Shunting for Hydrocephalus after Subarachnoid Hemorrhage.Neurologia medico-chirurgica · 2025Article
- Faster Decay of Cerebrospinal Fluid Red Blood Cells and Total Protein Predict Good Functional Outcome After Subarachnoid Hemorrhage.European journal of neurology · 2025Article
- Red Blood Cells in the Cerebrospinal Fluid Compartment After Subarachnoid Haemorrhage: Significance and Emerging Therapeutic Strategies.Translational stroke research · 2025Review
- Cerebrospinal fluid red blood cells and total protein are associated with clinical outcome in spontaneous subarachnoid hemorrhage.European journal of neurology · 2025Observational
- Temporal Changes in CSF Cell Parameters After SAH: Comparison of Ventricular and Spinal Drain Samples.Neurocritical care · 2024Article
- Red blood cell count in cerebrospinal fluid was correlated with inflammatory markers on the seventh postoperative day and all associated with the outcome of aneurysmal subarachnoid hemorrhage patients.Frontiers in medicine · 2024Article
- Subarachnoid haemorrhage or traumatic lumbar puncture. Differentiation by cerebrospinal fluid parameters in a multivariable approach.Scientific reports · 2023Article
- Brain MRI activity during the year before pregnancy can predict long-term clinical worsening in patients with Multiple Sclerosis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023Observational
- Immunological Profile of Vasospasm after Subarachnoid Hemorrhage.International journal of molecular sciences · 2023Review
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Spontaneous subarachnoid hemorrhage (SAH) is a severe neurological disease that frequently requires placement of external ventricular drainage (EVD). Cerebrospinal fluid (CSF) obtained Objective: This study aimed to describe the longitudinal profile of routine CSF parameters in patients with SAH and to identify associations with neurological complications. Methods: A total of thirty-three patients with spontaneous SAH who required an EVD and had at least three consecutive CSF samples collected over a period of more than 7 days were included in this study. Results: A median of 6 longitudinally collected CSF samples per patient were available within 1-22 days after SAH onset. Overall, red blood cells (RBC) steadily decreased over time, whereas white blood cells (WBC) and total protein (TP) increased until days 6 and 13, respectively, and decreased thereafter. The estimated decay rates of RBC, WBC, and TP were 28, 22, and 6% per day. Distinct CSF patterns over time were linked to known complications after SAH. Patients with rebleeding showed increased RBC, TP, and phagocytosing cells compared to patients without re-bleeding. For ventriculitis, an elevated cell index with a higher proportion of granulocytes was characteristic. CSF of patients with delayed cerebral ischemia showed increased RBC and WBC compared to patients without DCI. Early CSF WBC and cell index were predictive for the occurrence of DCI and ventriculitis later during the disease course. The amount of daily CSF drainage Conclusion: Longitudinal CSF characteristics are associated with SAH-related complications.
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