Evidence map›Paper›PMID 35959353›Full record

ArticleComputational and mathematical methods in medicine2022

A Novel Strategy for the Treatment of Allergic Rhinitis: Regulating Treg/Th17 and Th1/Th2 Balance In Vivo by Vitamin D.

Baowei Li, Xiaoli Zhang, Zhezhe Sun, Bingxin Xu, Jihua Wu, Hongdan Liu, Haolun Han, Lei Wang, Wei Wu

RetractedOpen access · hybridAbstract readRetracted Publication
In one paragraph

Article in Computational and mathematical methods in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Serum vitamin DJournal of thoracic disease · 2023
    Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Baowei LiDepartment of Otolaryngology, Strategic Support Forces Medical Center, Beijing 100101, China.
Xiaoli ZhangDepartment of Otolaryngology, Strategic Support Forces Medical Center, Beijing 100101, China.
Zhezhe SunDepartment of Otolaryngology, Strategic Support Forces Medical Center, Beijing 100101, China.
Bingxin XuDivision Two, Strategic Support Forces Medical Center, Beijing 100101, China.
Jihua WuDepartment of Pathology, Strategic Support Forces Medical Center, Beijing 100101, China.
Hongdan LiuDepartment of Otolaryngology, Strategic Support Forces Medical Center, Beijing 100101, China.
Haolun HanDepartment of Otolaryngology, Strategic Support Forces Medical Center, Beijing 100101, China.
Lei WangDepartment of Otolaryngology, Strategic Support Forces Medical Center, Beijing 100101, China.
Wei WuDepartment of Otolaryngology, Strategic Support Forces Medical Center, Beijing 100101, China.ORCID https://orcid.org/0000-0003-3694-855X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: This prospective study is aimed at observing the number of nasal itching and sneezing in rats from the macroscopic level and examine the pathological changes of nasal mucosa, Th1 and Th2-related cytokines, and Treg/Th17 by vitamin D3 administration from the microscopic level, in order to explore the role of vitamin D in allergic rhinitis and to provide theoretical guidance for prevention and treatment. Results: There were significant differences in nasal itching and sneezing between the administration groups and the positive groups. Meanwhile, the level of Th1 and Treg in the administration groups increased, while the level of Th2 and Th17 decreased, indicating that the balance of Th1/Th2 was corrected. Our study revealed that vitamin D3 has preventive and therapeutic effects on allergic rhinitis, which provides theoretical guidance for practical application.

Indexed as

Rhinitis, AllergicT-Lymphocytes, RegulatoryAnimalsCholecalciferolCytokinesDisease Models, AnimalProspective StudiesPruritusRatsSneezingVitamin DCholecalciferolCytokinesVitamin D

Identifiers

PMID35959353
PMCPMC9357782
OpenAlexW4289131295

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.