Construction of Biologic Microscopic Image Segmentation Model Based on Smoothing of Fourth-Order Partial Differential Equation.

In order to solve the problem of microscopic image noise, a biological microscopic image segmentation model based on the smoothing of the fourth-order partial differential equation was proposed. Based on the functional description of image smoothness by directional curvature mode value, a fourth-order PDE image denoising model is derived, which can effectively reduce noise while preserving edges. The result of this method is piecewise linear image, and the gradient at the edge of the target has a step. Using the feature of noise reduction, a new geodesic active contour model is proposed. The experiment result shows that when the variance of Gaussian white noise is 15, the enhancement and denoising effects of the proposed method are 80.35% and 69.84 higher than those of the original vibration filtering method and L. Alvarez method. In terms of time, the proposed method is 1.3075 seconds slower than the original vibration filtering method and 17.5754 seconds faster than the L. Alvarez method. When the variance of Gaussian white noise is 25, the enhancement and denoising effects of the proposed method are 97.79% and 81.16 higher than those of the original vibration filtering method and L. Alvarez method. In terms of time, the proposed method is 1.3246 seconds slower than the original vibration filtering method and 17.5796 seconds faster than the L. Alvarez method.