Evidence map›Paper›PMID 35958972›Full record

ReviewInnovations in clinical neuroscience

Implementing Digital Technologies in Clinical Trials: Lessons Learned.

Georgia Mitsi, Todd Grinnell, Suzanne Giordano, Thomas Goodin, Shahin Sanjar, Elizabeth Marble, Andrei Pikalov

Abstract readReview
In one paragraph

Review in Innovations in clinical neuroscience. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Review
  3. Continuous Monitoring of Head Turns: Compliance, Kinematics, and Reliability of Wearable Sensing.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2025
    Article
  4. Article
  5. Review
  6. Review
  7. Digital Solutions Observed in Clinical Trials: A Formative Feasibility Scoping Review.AMIA ... Annual Symposium proceedings. AMIA Symposium · 2023
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Georgia MitsiAll authors are with Sunovion Pharmaceuticals Inc. in Marlborough, Massachusetts.
Todd GrinnellAll authors are with Sunovion Pharmaceuticals Inc. in Marlborough, Massachusetts.
Suzanne GiordanoAll authors are with Sunovion Pharmaceuticals Inc. in Marlborough, Massachusetts.
Thomas GoodinAll authors are with Sunovion Pharmaceuticals Inc. in Marlborough, Massachusetts.
Shahin SanjarAll authors are with Sunovion Pharmaceuticals Inc. in Marlborough, Massachusetts.
Elizabeth MarbleAll authors are with Sunovion Pharmaceuticals Inc. in Marlborough, Massachusetts.
Andrei PikalovAll authors are with Sunovion Pharmaceuticals Inc. in Marlborough, Massachusetts.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multiple digital health technologies have been evaluated across clinical development programs, including external, wearable, implantable, and ingestible devices and sensors, along with digital mobile health applications (apps) that are accessible via users' personal electronic devices (e.g., smartphones, tablets, and computers). Several of these technologies have been incorporated into our ongoing neurology and respiratory clinical development programs. Based on our experience, one of the greatest potential benefits of digital health technologies is the ability to collect objective and/or biological data continuously or at regular intervals outside of office visits during a patient's normal daily activities to provide additional efficacy and safety information, versus data capture from traditional episodic, time point-based office visits. Many challenges encountered with digital health technologies can be successfully addressed by providing the appropriate training to staff and patients, ensuring availability of appropriate infrastructure support, and conducting pilot studies before scaling up to larger trials. Overall, our experience with digital health technologies demonstrated their potential to increase the amount of objective data collected in clinical trials, expand patient access to trials, and facilitate further improvement of clinical outcomes.

Indexed as

Clinical trialsdigital health technologiesmachine learningmobile applicationswearables

Identifiers

PMID35958972
PMCPMC9341314

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.