ArticleJACC. Basic to translational science2022
Long-Term Strenuous Exercise Promotes Vascular Injury by Selectively Damaging the Tunica Media: Experimental Evidence.
Article in JACC. Basic to translational science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 18 citations in OpenAlex.
- Monckeberg's Medial Sclerosis in Athletes: Report of Two Cases and Possible Pathophysiological Mechanisms.Diagnostics (Basel, Switzerland) · 2026Article
- Association of physical activity with arterial stiffness: the mediating role of the visceral fat metabolism score.Archives of endocrinology and metabolism · 2026Article
- Increases in Strain, Strain Rate, Displacement and Velocity in the Thoracic Aorta After Bench Pressing.Medicina (Kaunas, Lithuania) · 2025Observational
- The regulatory role of exercise in heart failure and myocardial energy metabolism: A review.Biomolecules & biomedicine · 2025Review
- Athlete's Heart Revisited: Historical, Clinical, and Molecular Perspectives.Circulation research · 2025Review
- Carotid intima-media thickness, cardiovascular disease, and risk factors in 29,000 UK Biobank adults.American journal of preventive cardiology · 2025Article
- Article
- No causal association between the volume of strenuous exercise and coronary atherosclerosis: a two-sample Mendelian randomization study.Frontiers in cardiovascular medicine · 2024Article
- Regular exercise delays microvascular endothelial dysfunction by regulating antioxidant capacity and cellular metabolism.Scientific reports · 2023Article
- The extracellular matrix mechanics in the vasculature.Nature cardiovascular research · 2023Review
- High-Intensity Exercise Promotes Deleterious Cardiovascular Remodeling in a High-Cardiovascular-Risk Model: A Role for Oxidative Stress.Antioxidants (Basel, Switzerland) · 2023Article
- Lifelong endurance exercise and its relation with coronary atherosclerosis.European heart journal · 2023Observational
- Something is moving in sports-related sudden cardiac death … is it time to change our minds?Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2023Article
- Injury to the tunica media initiates atherogenesis in the presence of hyperlipidemia.Frontiers in cardiovascular medicine · 2023Article
- Intense long-term training impairs brain health compared with moderate exercise: Experimental evidence and mechanisms.Annals of the New York Academy of Sciences · 2022Article
- Antioxidant Molecular Brain Changes Parallel Adaptive Cardiovascular Response to Forced Running in Mice.Antioxidants (Basel, Switzerland) · 2022Article
- Exercise at the Extremes: Unraveling the Mechanisms of Deleterious Cardiovascular Adaptations.JACC. Basic to translational science · 2022Article
- Vascular homeostasis in atherosclerosis: A holistic overview.Frontiers in immunology · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Moderate exercise has well-founded benefits in cardiovascular health. However, increasing, yet controversial, evidence suggests that extremely trained athletes may not be protected from cardiovascular events as much as moderately trained individuals. In our rodent model, intensive but not moderate training promoted aorta and carotid stiffening and elastic lamina ruptures, tunica media thickening of intramyocardial arteries, and an imbalance between vasoconstrictor and relaxation agents. An up-regulation of angiotensin-converter enzyme, miR-212, miR-132, and miR-146b might account for this deleterious remodeling. Most changes remained after a 4-week detraining. In conclusion, our results suggest that intensive training blunts the benefits of moderate exercise.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.