Evidence map›Paper›PMID 35958695›Full record

ArticleJACC. Basic to translational science2022

Reduced Proteolytic Cleavage of von Willebrand Factor Leads to Aortic Valve Stenosis and Load-Dependent Ventricular Remodeling.

Koya Ozawa, Matthew A Muller, Oleg Varlamov, Matthew W Hagen, William Packwood, Terry K Morgan, Aris Xie, Claudia S López, Dominic Chung, Junmei Chen and 2 more

Erratum issued Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Basic to translational science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT05550896 (Platelet Adhesion in the Pathobiology of Aortic Stenosis), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05550896 active not recruitingnot on this mapstarted 2023, after this paper: background citation

Platelet Adhesion in the Pathobiology of Aortic Stenosis

TypeobservationalSponsorUniversity of VirginiaRan2023 to 2028Enrolled65ConditionsAortic Valve StenosisArmsEchocardiogaphy
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Koya OzawaKnight Cardiovascular Institute, Oregon Health & Science University, Portland, Oregon, USA.
Matthew A MullerKnight Cardiovascular Institute, Oregon Health & Science University, Portland, Oregon, USA.
Oleg VarlamovOregon National Primate Research Center, Oregon Health & Science University, Portland, Oregon, USA.
Matthew W HagenKnight Cardiovascular Institute, Oregon Health & Science University, Portland, Oregon, USA.
William PackwoodKnight Cardiovascular Institute, Oregon Health & Science University, Portland, Oregon, USA.
Terry K MorganDepartment of Pathology, Oregon Health & Science University, Portland, Oregon, USA.
Aris XieKnight Cardiovascular Institute, Oregon Health & Science University, Portland, Oregon, USA.
Claudia S LópezDepartment of Biomedical Engineering, Oregon Health & Science University, Portland, Oregon, USA.
Dominic ChungBloodWorks NW, Seattle, Washington, USA.
Junmei ChenBloodWorks NW, Seattle, Washington, USA.
José A LópezBloodWorks NW, Seattle, Washington, USA.
Jonathan R LindnerKnight Cardiovascular Institute, Oregon Health & Science University, Portland, Oregon, USA.
Oregon Health & Science University · USBloodworks Northwest · USOregon National Primate Research Center · US

Funding

Upgrade of confocal microscopy at the Oregon National Primate Research CenterP51OD011092 · OD · OREGON HEALTH & SCIENCE UNIVERSITY · PI Bonnie J. Nagel · 2012 to 2026
$203.9M
NIH HHS P51 OD011092
6 · The paper itself

Abstract

We hypothesized that excess endothelial-associated von Willebrand factor (vWF) and secondary platelet adhesion contribute to aortic valve stenosis (AS). We studied hyperlipidemic mice lacking ADAMTS13 (

Indexed as

aortic valve stenosisAS, aortic valve stenosisechocardiographyMMP, matrix metalloproteinasePMV, platelet microvesiclespSMAD2, phosphorylated SMAD2TGF, transforming growth factorVEC, valvular endothelial cellVIC, valvular interstitial cellvon Willebrand factorvWF, von Willebrand factorWSD, Western-style diet

Identifiers

PMID35958695
PMCPMC9357566
OpenAlexW4286781300

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.