Evidence map›Paper›PMID 35958672›Full record

ArticleJAMIA open2022

Case report: evaluation of an open-source synthetic data platform for simulation studies.

Daniella Meeker, Crystal Kallem, Yan Heras, Stephanie Garcia, Casey Thompson

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in JAMIA open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. MIMIC-IV on FHIR: converting a decade of in-patient data into an exchangeable, interoperable format.Journal of the American Medical Informatics Association : JAMIA · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Daniella MeekerKeck School of Medicine, University of Southern California, Los Angeles, California, USA.
Crystal KallemClinovations Government+Health, Washington, District of Columbia, USA.
Yan HerasOptimum eHealth, LLC, Irvine, California, USA.
Stephanie GarciaOffice of the National Coordinator for Health Information Technology, Washington, District of Columbia, USA.
Casey ThompsonClinovations Government+Health, Washington, District of Columbia, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Simulation is a mainstay of comparative- and cost-effectiveness research when empirical data are not available. The Synthea platform, originally designed for generating realistically coded longitudinal health records for software testing, implements data generation models specified in publicly contributed modules representing patients' life cycle and disease and treatment progression. We test the hypothesis that Synthea can be used for simulation studies that draw parameters from observational studies and randomized trials. We benchmarked the results and assessed the effort required to create a Synthea module that replicates a recently published cost-effectiveness simulation comparing levofloxacin prophylaxis to usual care for leukemia. A module was iteratively developed using published parameters from the original study; we replicated the initial conditions and simulation endpoints of demographics, health events, costs, and mortality. We compare Synthea's Generic Module Framework to platforms designed for simulation and show that Synthea can be used, with modifications, for some types of simulation studies.

Indexed as

computer simulationElectronic Health Recordsleukemiaprivacysoftware validation

Identifiers

PMID35958672
PMCPMC9360775

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.