ReviewAnnals of cardiothoracic surgery2022
Normal and abnormal development of the aortic valve and ascending aortic wall: a comprehensive overview of the embryology and pathology of the bicuspid aortic valve.
Review in Annals of cardiothoracic surgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 35 citations in OpenAlex.
- Bicuspid Aortic Valve Disease-Associated Aortopathy in Pediatric Subjects-From Traditional Assessment to Current Advances and Future Perspectives: A Narrative Review.Medical sciences (Basel, Switzerland) · 2026Review
- Brief Review: Racial Disparities in the Presentation and Outcomes of Patients with Thoracic Aortic Aneurysms.Journal of cardiovascular development and disease · 2025Review
- Tissue-specific lncRNA GATA6-AS1 and its ortholog Moshe as essential regulators of aortic valve development.BMB reports · 2025Article
- Bicuspid Aortic Valve, from the Unknown till the Perfection of the Species.Reviews in cardiovascular medicine · 2024Review
- Cellular, Molecular and Clinical Aspects of Aortic Aneurysm-Vascular Physiology and Pathophysiology.Cells · 2024Review
- Aortic Valve Embryology, Mechanobiology, and Second Messenger Pathways: Implications for Clinical Practice.Journal of cardiovascular development and disease · 2024Review
- Is the intimal thickness a key contributor to thoracic aortopathy?Indian journal of thoracic and cardiovascular surgery · 2023Article
- The role of transforming growth factor beta in bicuspid aortic valve aortopathy.Indian journal of thoracic and cardiovascular surgery · 2023Article
- The Prevalence of Coronary Artery Disease in Bicuspid Aortic Valve Patients: An Overview of the Literature.Aorta (Stamford, Conn.) · 2023Article
- Evidence Accumulates: Patients with Ascending Aneurysms Are Strongly Protected from Atherosclerotic Disease.International journal of molecular sciences · 2023Review
- A case of multiple median sternotomy for infection and expanding hematoma in 10 years.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2023Article
- Thoracic aortic atherosclerosis in patients with a bicuspid aortic valve; a case-control study.BMC cardiovascular disorders · 2023Article
- Commentary: Transforming growth factor serum concentrations in patients with proven non-syndromic aortopathy.Frontiers in cardiovascular medicine · 2023Article
- Adventitial adaptive immune cells are associated with ascending aortic dilatation in patients with a bicuspid aortic valve.Frontiers in cardiovascular medicine · 2023Article
- Thoracic aortopathy in Marfan syndrome overlaps with mechanisms seen in bicuspid aortic valve disease.Frontiers in cardiovascular medicine · 2023Article
- Risk for acquired coronary artery disease in genetic vs. congenital thoracic aortopathy.Frontiers in cardiovascular medicine · 2022Article
- Are acute type A aortic dissections atherosclerotic?Frontiers in cardiovascular medicine · 2022Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A bicuspid aortic valve (BAV) is the most prevalent congenital cardiac anomaly, in which the valve has only two leaflets, instead of the normal three. Patients with a BAV have an increased risk of aneurysm formation and the development of an aortic dissection. Vascular smooth muscle cells in both the non- and dilated aortic wall are characterized by a maturation defect in all BAV patients, as compared to patients with a tricuspid aortic valve, which can contribute to inherent developmental susceptibility. Besides structural abnormalities of the vascular wall, a turbulent blood flow, caused by bicuspid valve geometry, could expedite the pathological process in the aortic wall, leading to aortopathy. Although the risk for aortopathy is significant, not all BAV patients experience (acute) aortic complications in their lifespan, highlighting the complexity of the pathogenetic process. Recent studies have focused on the embryonic development of semilunar valves and the ascending aortic wall. Their findings highlight that a defect in the embryogenesis could not only explain the development of a malformed aortic valve but also the increased risk for ascending aorta and arch pathology. This review presents an overview of the normal and abnormal development of the aortic valve and the aortic wall: a common defect in early embryogenesis causes the development of a BAV and associated aortopathy.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.