ArticleEClinicalMedicine2022
Association of the depressive scores, depressive symptoms, and conversion patterns of depressive symptoms with the risk of new-onset chronic diseases and multimorbidity in the middle-aged and elderly Chinese population.
Article in EClinicalMedicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- The role of the amygdala in depression: a bibliometric analysis (2015-2024).Frontiers in psychiatry · 2025Pooled it
- Depression and risk of incident heart diseases among older adults at CKM stages 0-3: evidence from the China Health and Retirement Longitudinal Study.Annals of medicine · 2026Article
- Article
- Multidimensional analysis of depression and diabetic kidney disease using GBD, NHANES, and MR.iScience · 2026Article
- Association between depression and chronic lung diseases in older Chinese adults: a national cross-sectional study.BMC public health · 2026Article
- Integrating Vascular Aging and Genetic Risk: The Combined Impact of Estimated Pulse Wave Velocity and Genetic Predisposition on Coronary Artery Disease.Journal of the American Heart Association · 2025Article
- Identifying Important Factors for Depressive Symptom Dynamics in Chinese Middle-Aged and Older Adults Using a Multi-State Transition Model with Feature Selection.Behavioral sciences (Basel, Switzerland) · 2025Article
- Beyond association: Examining overweight as a mediator in the link between depression and diabetes.World journal of diabetes · 2025Article
- CHARLS insights into the impact of dual interactions of chronic diseases on depression in middle-aged and elderly individuals.Scientific reports · 2025Article
- Association between depressive symptoms and thyroid nodule incidence in women: a prospective observational study.BMC public health · 2025Observational
- Association between chronic diseases and depressive inclinations among rural middle-aged and older adults.Scientific reports · 2025Article
- Cross-national statistical harmonization of the Center for Epidemiologic Studies Depression (CES-D) scale among older adults in China, England, India, Mexico, South Africa, and the United States.Journal of clinical epidemiology · 2025Article
- Limosilactobacillus-related 3-OMDP as a potential therapeutic target for depression.Annals of medicine · 2024Article
- Functional magnetic resonance imaging of depression: a bibliometrics and meta-analysis.Annals of general psychiatry · 2024Article
- Decomposition Analysis of Depressive Symptom Differences Among Older Adults With Hypertension Between Urban and Rural Areas: Cross-Sectional Study.JMIR public health and surveillance · 2024Article
- Cardiometabolic index and the risk of new-onset chronic diseases: results of a national prospective longitudinal study.Frontiers in endocrinology · 2024Article
- Identifying the subgroups of depression trajectories among the middle-aged and older Chinese individuals with chronic diseases: an 8-year follow-up study based on CHARLS.Frontiers in public health · 2024Article
- Depressive Symptoms and Sleep Duration as Risk Factors for Breast Cancer - China, 2020.China CDC weekly · 2023Article
- Association between chronic diseases and depression in the middle-aged and older adult Chinese population-a seven-year follow-up study based on CHARLS.Frontiers in public health · 2023Article
- A study on the influence of community spiritual comfort service on the mental health of older people.Frontiers in public health · 2023Article
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The relationship between depressive symptoms (DS) and their conversion patterns over time and the new-onset risk of diseases in the middle-aged and elderly population has not been extensively studied. Methods: Based on The China Health and Retirement Longitudinal Study participants in 2013, we established 13 cohorts involving 12 types of chronic diseases and multimorbidity, who were identified by face-to-face questionnaires. We retrospectively assessed their DS during 2011 and 2013 through the 10-item Center for Epidemiological Studies Depression Scale (CES-D), which were classified into never, newly developed, relieved, and persistent DS, and these participants were followed from 2013 to 2018. Findings: CES-D scores were new-onset risk factors for 9 diseases. The new-onset risk of diseases increased with higher CES-D scores. When CES-D scores were higher than approximately 6, the hazard ratios (HRs) of emergent diseases were greater than 1. DS was independent new-onset risk factors for 8 diseases, with HRs (95% CI) ranging from 1.2635 (1.0061-1.5867) to 1.5231 (1.0717-2.165). Persistent DS was an independent risk factor for most diseases but might be an independent protective factor for new-onset cancer (HR, 95% CI: 0.276, 0.106-0.723). Interpretation: DS is closely associated with new-onset risk of chronic diseases and multimorbidity, and awareness of the risk associated with pre-DS status (6<CES-D<12) should be raised. chronic disease risks were almost lower with newly developed and relieved DS than with persistent DS, suggesting the potential benefits of active management of DS to reduce the risk of emergent diseases in middle-aged and elderly population. Funding: National Natural Science Foundation of China.
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