ArticleAmerican journal of translational research2022
Characterization of antidepressant activity of
Article in American journal of translational research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Genetic diversity and population structure of the vulnerable medicinal tree Saraca asoca in the Western Ghats India.Scientific reports · 2025Article
- Hypoxic preconditioning modulates BDNF signaling to alleviate depression-like behaviors in mice and its whole transcriptome sequencing analysis.Scientific reports · 2025Article
- Quinoline conjugates for enhanced antimalarial activity: a review on synthesis by molecular hybridization and structure-activity relationship (SAR) investigation.American journal of translational research · 2025Review
- Kif15 deficiency contributes to depression-like behavior in mice.Metabolic brain disease · 2023Article
- Flavonols in Action: Targeting Oxidative Stress and Neuroinflammation in Major Depressive Disorder.International journal of molecular sciences · 2023Review
- Efficacy of 15% lysine cream in treating diabetic foot ulcers: a randomized interventional study.International journal of physiology, pathophysiology and pharmacology · 2023Article
- Acute and chronic toxicity studies on ethanolic leaf extracts ofInternational journal of biochemistry and molecular biology · 2022Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLong-term stress and chronic stress events play an important role in the etiology of depression. The study aimed to investigate the antidepressant-like effect of freshly prepared crude ethanolic extract of METHODOLOGY:
resultsThe oral administration of ESAF in doses of 50, 100, & 250 mg/kg for seven consecutive days gave a significant decrease in the time of immobility (P<0.05) and reversed the depression-like behavior induced by acute restraint methods and behavioral models. ESAF treated groups showed a significant increase in glutathione peroxidase (GSH-PX) activity in the hippocampus of the acutely restrained mice. In addition, ESAF 250 mg/kg reduced plasma corticosterone levels in mice subjected to different forms of acute restraint stress compared to other groups, comparable to the standard imipramine.
conclusionOur study showed the antidepressant activity of the ESAF. This effect may be attributed to the presence of antioxidant bioflavonoids namely,
Indexed as
Identifiers
35958453PMC9360865What OpenQuestion holds
Registered trials
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