SynthesisFrontiers in cardiovascular medicine2022
The incidence and risk of venous thromboembolism associated with peripherally inserted central venous catheters in hospitalized patients: A systematic review and meta-analysis.
Synthesis in Frontiers in cardiovascular medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Association of Anaesthetists guidelines: safe vascular access 2025.Anaesthesia · 2025Guideline
- Development and preliminary validation of a PICC-related venous thrombosis risk prediction model for cancer patients: A systematic review and meta-analysis predominantly based on Chinese populations.Asia-Pacific journal of oncology nursing · 2026Review
- Inflammation-coagulation biomarkers predict catheter-related thrombosis following peripherally inserted central catheter placement in patients with hematologic malignancies: a retrospective cohort study.Translational cancer research · 2026Article
- Thrombus Formation and Peripherally Inserted Central Catheter-Related Infection: A Retrospective Observational Study.Nursing open · 2026Observational
- Peripherally inserted central catheters versus central venous catheters in critically ill patients under standardized insertion protocols: a propensity score-matched cohort study.BMC anesthesiology · 2026Article
- Neonatal epicutaneo-cava catheter-related thrombosis: a comprehensive overview.Thrombosis journal · 2026Review
- Construction and Validation of a Risk Prediction Model for Postoperative Lower Extremity Deep Vein Thrombosis in Patients with Vascular Access Devices: A Retrospective Analysis.Vascular health and risk management · 2026Article
- Observational
- Outcomes of a bedside ultrasound-guided peripherally-inserted central catheter placement across critically-ill older patients.PloS one · 2026Article
- Management of Upper Extremity DVT.Seminars in interventional radiology · 2025Review
- Assessing Venous Thromboembolism Incidence and Risk Factors: a Narrative Review.Materia socio-medica · 2025Article
- A Comprehensive Review of Catheter-Related Thrombosis.Journal of clinical medicine · 2024Review
- Experience of a vascular ultrasound-guided program: from the ICU to the hospital.The ultrasound journal · 2024Article
- Article
- Central Venous Catheters versus Peripherally Inserted Central Catheters: A Comparison of Indwelling Time Resulting in Colonization by Multidrug-Resistant Pathogens.Antibiotics (Basel, Switzerland) · 2024Article
- Clinical applications and research progress of totally implantable venous access ports: a literature review.Frontiers in oncology · 2024Review
- Anatomical Structures to Be Concerned With During Peripherally Inserted Central Catheter Procedures.Journal of Korean medical science · 2023Article
- Risk Factors and Clinical Outcomes of Upper Extremity Deep-Vein Thrombosis in Critically Ill Patients: A Retrospective Cohort Study.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/HemostasisArticle
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Venous thromboembolism (VTE) can be fatal if not treated promptly, and individual studies have reported wide variability in rates of VTE associated with peripherally inserted central catheters (PICC). We thus conducted this meta-analysis to investigate the overall incidence and risk of developing PICC-related VTE in hospitalized patients. Methods: We searched PubMed, Embase, Scopus, and Web of Science databases from inception until January 26, 2022. In studies with a non-comparison arm, the pooled incidence of PICC-related VTE was calculated. The pooled odds ratio (OR) was calculated to assess the risk of VTE in the studies that compared PICC to the central venous catheter (CVC). The Newcastle-Ottawa Scale was used to assess methodological quality. Results: A total of 75 articles (58 without a comparison arm and 17 with), including 109292 patients, were included in the meta-analysis. The overall pooled incidence of symptomatic VTE was 3.7% (95% CI: 3.1-4.4) in non-comparative studies. In the subgroup meta-analysis, the incidence of VTE was highest in patients who were in a critical care setting (10.6%; 95% CI: 5.0-17.7). Meta-analysis of comparative studies revealed that PICC was associated with a statistically significant increase in the odds of VTE events compared with CVC (OR, 2.48; 95% CI, 1.83-3.37; Conclusion: Best practice standards such as PICC tip verification and VTE prophylaxis can help reduce the incidence and risk of PICC-related VTE. The risk-benefit of inserting PICC should be carefully weighed, especially in critically ill patients. Cautious interpretation of our results is important owing to substantial heterogeneity among the studies included in this study.
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