ArticleFrontiers in nutrition2022
Compound dietary fiber and high-grade protein diet improves glycemic control and ameliorates diabetes and its comorbidities through remodeling the gut microbiota in mice.
Article in Frontiers in nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed, 22 citations in OpenAlex.
- A Synbiotic of Lacto-Nutrients · 2026Article
- Investigating the Role of Carbohydrates Quantity and Quality in the Incidence of Metabolic Syndrome: A Two-Year Cohort Study : Short title: Fat and Sleep Quality.Galen medical journal · 2026Article
- Essence of Chicken Supplementation Alters Brain and Blood Metabolite Signatures in Sleep-Deprived Mice.Metabolites · 2025Article
- Association of the newly proposed dietary index for gut microbiota and hyperlipidemia: From the 2007-2020 NHANES study.PloS one · 2025Article
- Retinal Vein Occlusion-Background Knowledge and Foreground Knowledge Prospects-A Review.Journal of clinical medicine · 2024Review
- Chronodisruption and Gut Microbiota: Triggering Glycemic Imbalance in People with Type 2 Diabetes.Nutrients · 2024Review
- The effects of using Tempeh as a supplement for type 2 diabetes.Food science & nutrition · 2023Article
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
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Abstract
Dietary intervention with a low glycemic index and full nutritional support is emerging as an effective strategy for diabetes management. Here, we found that the treatment of a novel compound dietary fiber and high-grade protein diet (CFP) improved glycemic control and insulin resistance in streptozotocin-induced diabetic mice, with a similar effect to liraglutide. In addition, CFP treatment ameliorated diabetes-related metabolic syndromes, such as hyperlipidemia, hepatic lipid accumulation and adipogenesis, systemic inflammation, and diabetes-related kidney damage. These results were greatly associated with enhanced gut barrier function and altered gut microbiota composition and function, especially those bacteria, microbial functions, and metabolites related to amino acid metabolism. Importantly, no adverse effect of CFP was found in our study, and CFP exerted a wider arrange of protection against diabetes than liraglutide. Thereby, fortification with balanced dietary fiber and high-grade protein, like CFP, might be an effective strategy for the management and treatment of diabetes.
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