Evidence map›Paper›PMID 35957988›Full record

ArticleFrontiers in physiology2022

Circadian Oscillations in the Murine Preoptic Area Are Reset by Temperature, but Not Light.

Nicolás M Díaz, Shannon A Gordon, Richard A Lang, Ethan D Buhr

Open access · goldAbstract read
In one paragraph

Article in Frontiers in physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Nicolás M DíazDepartment of Ophthalmology, University of Washington School of Medicine, Seattle, WA, United States.
Shannon A GordonDepartment of Ophthalmology, University of Washington School of Medicine, Seattle, WA, United States.
Richard A LangScience of Light Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.
Ethan D BuhrDepartment of Ophthalmology, University of Washington School of Medicine, Seattle, WA, United States.
University of Washington · USUniversity of Cincinnati Medical Center · US

Funding

Regulation of vascular development in the eye by an opsin 5-dependent clockR01EY027077 · NEI · CINCINNATI CHILDRENS HOSP MED CTR · PI LANG, RICHARD A., RAO, SUJATA · 2016 to 2020
$2.4M
The role of OPN5 in extraocular circadian photoentrainment in mammalsR01GM124246 · NIGMS · UNIVERSITY OF WASHINGTON · PI BUHR, ETHAN D · 2017 to 2021
$1.9M
Light regulated vascular development in the eye via the Hippo pathwayR01EY032029 · NEI · CINCINNATI CHILDRENS HOSP MED CTR · PI LANG, RICHARD A., XIN, MEI · 2021 to 2024
$1.6M
NEI NIH HHS R01 EY027077NEI NIH HHS R01 EY032029NIGMS NIH HHS R01 GM124246
6 · The paper itself

Abstract

Mammals maintain their internal body temperature within a physiologically optimal range. This involves the regulation of core body temperature in response to changing environmental temperatures and a natural circadian oscillation of internal temperatures. The preoptic area (POA) of the hypothalamus coordinates body temperature by responding to both external temperature cues and internal brain temperature. Here we describe an autonomous circadian clock system in the murine ventromedial POA (VMPO) in close proximity to cells which express the atypical violet-light sensitive opsin, Opn5. We analyzed the light-sensitivity and thermal-sensitivity of the VMPO circadian clocks

Indexed as

circadian rhythmneuropsinOpn5preoptic areatemperature

Identifiers

PMID35957988
PMCPMC9361018
OpenAlexW4287960387

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.