Evidence map›Paper›PMID 35957872›Full record

ArticleFrontiers in oncology2022

Paeoniflorin Inhibits EMT and Angiogenesis in Human Glioblastoma

Zhi Liu, Zhaotao Wang, Danmin Chen, Xiaorui Liu, Guoyong Yu, Yan Zhang, Chen Chen, Ruxiang Xu, Yezhong Wang, Ru-En Liu

Open access · goldAbstract read
In one paragraph

Article in Frontiers in oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Zhi LiuDepartment of Neurosurgery, Peking University People's Hospital, Peking University, Beijing, China.
Zhaotao WangDepartment of Neurosurgery, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, China.
Danmin ChenDepartment of Neurosurgery, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, China.
Xiaorui LiuDepartment of Pharmacy, Affiliated Cancer Hospital and Institute of Guangzhou Medical University, Guangzhou, China.
Guoyong YuDepartment of Neurosurgery, Peking University People's Hospital, Peking University, Beijing, China.
Yan ZhangAffiliated Bayi Brain Hospital, The Seventh Medical Center of PLA General Hospital, Beijing, China.
Chen ChenAffiliated Bayi Brain Hospital, The Seventh Medical Center of PLA General Hospital, Beijing, China.
Ruxiang XuAffiliated Bayi Brain Hospital, The Seventh Medical Center of PLA General Hospital, Beijing, China.
Yezhong WangDepartment of Neurosurgery, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, China.
Ru-En LiuDepartment of Neurosurgery, Peking University People's Hospital, Peking University, Beijing, China.
Bayi Children's Hospital · CNGuangzhou Medical University · CNPeking University · CNSecond Affiliated Hospital of Guangzhou Medical University · CNPeking University People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Epithelial-to-mesenchymal transition (EMT) and angiogenesis have emerged as two pivotal events in cancer progression. Paeoniflorin has been widely studied in experimental models and clinical trials for cancer treatment because of its anti-cancer property. However, the underlying mechanisms of paeoniflorin in EMT and angiogenesis in glioblastoma was not fully elucidated. The present study aimed to investigate whether paeoniflorin inhibits EMT and angiogenesis, which involving c-Met suppression, while exploring the potential ways of c-Met degradation. In our study, we found that paeoniflorin inhibited EMT

Indexed as

angiogenesisautophagyc-MetEMTglioblastomapaeoniflorinpolyubiquitination

Identifiers

PMID35957872
PMCPMC9360619
OpenAlexW4287921476

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.