ArticleJournal of ophthalmology2022
Relationship of Retinal Vessel Caliber with Age-Related Macular Degeneration.
Article in Journal of ophthalmology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00000145 (Age-Related Eye Disease Study), which is not on this map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Age-Related Eye Disease Study (AREDS)
Who cites it
18 citing papers in PubMed, 18 citations in OpenAlex.
- Non neovascular Age - related macular degeneration - Review on clinical and imaging advances.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Review
- Proteomic clocks combined with deep learning phenotypes track eye aging and diseases.NPJ digital medicine · 2026Article
- A Datasheet for the Age-Related Eye Disease Study (AREDS) on the database of Genotypes and Phenotypes.Ophthalmology science · 2026Article
- Factors Associated with Machine Learning-Based Predictions of Retinal Aging Using Teleretinal Screening Images from Patients with Diabetes.Ophthalmology science · 2026Article
- Lens opacity as a predictor of retinal vasculature change following cataract surgery.Scientific reports · 2025Article
- Ocular changes as potential biomarkers for early diagnosis of Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Review
- Correlation of retino-choroidal thickness and vascular metrics with drusen volume as a severity marker of age-related macular degeneration.Eye (London, England) · 2025Article
- Comprehensive genome-wide analysis of retinal vessel caliber reveals microvascular-blood pressure pathways: advancing predictive, preventive, and personalized medicine.The EPMA journal · 2025Article
- Effects of Physical Activity and Inactivity on Microvasculature in Children: The Hong Kong Children Eye Study.Investigative ophthalmology & visual science · 2024Article
- Alzheimer's disease pathophysiology in the Retina.Progress in retinal and eye research · 2024Review
- Personalizing Nutrition Strategies: Bridging Research and Public Health.Journal of personalized medicine · 2024Review
- The role of the retinal vasculature in age-related macular degeneration: a spotlight on OCTA.Eye (London, England) · 2024Review
- Choroidal Changes in Rhesus Macaques in Aging and Age-Related Drusen.Investigative ophthalmology & visual science · 2023Article
- Comparison of Ophthalmic Artery Morphological Characteristics and Retinal Vessel Diameter for Identifying Ocular Ischemic Syndrome.Investigative ophthalmology & visual science · 2023Observational
- Does the Presence of the Cilioretinal Artery Affect the Incidence, Clinical Picture and Progression of Age-Related Macular Degeneration?Diagnostics (Basel, Switzerland) · 2023Article
- Article
- Methods to measure blood flow and vascular reactivity in the retina.Frontiers in medicine · 2022Review
- Retinal Vessel Traits and Age-Related Eye Disease in the Canadian Longitudinal Study on Aging.Clinical & experimental ophthalmologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Purpose: Evaluate the relationship between retinal vascular caliber and age-related macular degeneration (AMD) severity or progression. Methods: A retrospective secondary analysis of 1172 fundus photographs and clinical data from the prospective Age-Related Eye Disease Study (AREDS). Central retinal artery equivalent (CRAE), central retinal vein equivalent (CRVE), and arteriole-to-venule ratio (AVR) were measured using the Parr-Hubbard-Knudtson formula. Univariate and multivariate regressions were used to determine the association of CRAE, CRVE, and AVR with age, sex, smoking status, presence of cilioretinal artery, and AMD severity at baseline and 5 years using the 9-step AMD severity score. Results: Only CRAE and CRVE were higher in men ( Conclusion: A lower arteriole-to-venule ratio may be associated with AMD severity, with narrower arterioles seen in the eyes with geographic atrophy, suggesting a role of the retinal vasculature in AMD pathophysiology. This trial is registered with ClinicalTrials.gov Identifier: NCT00000145.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.