ArticleAnnals of translational medicine2022
Age, gender, geographic and clinical differences for gallstones in China: a nationwide study.
Article in Annals of translational medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 44 citations in OpenAlex.
- Prevalence and metabolic correlates of gallbladder stones among community-dwelling older adults in Chongqing, China: a repeated cross-sectional study, 2018-2025.BMC gastroenterology · 2026Article
- Primary duct closure after laparoscopic common bile duct exploration in elderly patients with cholecystocholedocholithiasis: a propensity-matched analysis.BMC surgery · 2026Article
- Endoscopic ultrasound-guided gallbladder drainage and electrohydraulic lithotripsy for the treatment of gallbladder neck stones.Endoscopy · 2026Article
- Construction and validation of a diagnostic model for acute suppurative cholecystitis in older patients: LASSO-Logistic regression analysis using readily available clinical indicators.BMC geriatrics · 2026Article
- Lipid metabolism and gallstone disease risk: a multicenter study.Scientific reports · 2026Observational
- Reasons for delayed medical treatment among cholelithiasis patients: a qualitative study based on the health belief model.BMC health services research · 2026Article
- Cross-sectional associations of lipid accumulation and immune-nutritional indices with ultrasonography-detected gallstone disease: an explainable machine learning analysis.Frontiers in nutrition · 2026Article
- Better adherence to the life's essential 8 can reduce the risk of gallstone disease: mediated by inflammation and oxidative stress.Frontiers in public health · 2026Article
- Trends in Depression and Its Association With Gallstones: Evidence From NHANES With Exploration of Mediating Pathways.Depression and anxiety · 2026Article
- Article
- Association between triglyceride glucose index-related indices with gallbladder disease: a prospective cohort study in rural China.Scientific reports · 2025Article
- The Impact of Cholecystectomy on Colorectal Cancer Risk: A Comprehensive Review on Risk Factors and the Association.Current gastroenterology reports · 2025Review
- The mediating role of inflammatory factors in the relationship between obesity and gallstone disease: evidence from the NHANES 2017-2020.European journal of medical research · 2025Article
- Formation of non-cholesterol gallstones in populations within clonorchiasis endemic regions is closely related to Clonorchis sinensis infection.BMC gastroenterology · 2025Article
- Association between fibrosis-4 index (FIB-4) and gallstones: an analysis of the NHANES 2017-2020 cross-sectional study.BMC gastroenterology · 2025Article
- Effect of comprehensive perioperative nursing on pain intensity, complication rates, and comfort levels in patients undergoing gallstone surgery.World journal of gastrointestinal surgery · 2025Article
- Gallstones, cholecystectomy, and cancer risk: an observational and Mendelian randomization study.Frontiers of medicine · 2025Observational
- Body Mass Index mediates the relationship between estimated glucose disposal rate and gallstones.Scientific reports · 2025Article
- Endoscopic retrograde cholangiopancreatography combined with extracorporeal shock wave lithotripsy for the removal of large gallbladder stones: a pilot study.BMC gastroenterology · 2025Article
- Depressive symptoms mediate the association between sleep disorders and gallstone disease: a causal mediation analysis of NHANES 2017-2020.Frontiers in psychiatry · 2025Article
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
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Abstract
Background: The etiology of gallstones at different anatomical locations may be varied. However, it has not been well studied about the prevalence of gallstones by anatomical locations and their associated factors in China. Methods: We used the data set from preventive health screening centers covering all provinces in mainland China except for Tibet, and a total of 10,937,993 adults were included, who received abdominal ultrasonography in 2017. We analyzed the prevalence of gallstones classified by anatomical locations, including gallbladder (GB) stones, intrahepatic bile duct (IHD) stones, and extrahepatic bile duct (EHD) stones. Further, their associated factors were investigated using a logistic regression model with body mass index (BMI), fasting glucose, total triglyceride, and previous cholecystectomy, with covariates of age and sex. Results: The age- and gender-standardized prevalence (AGS-prevalence) of gallstone diseases was 5.13% (95% CI: 5.11-5.14%). GB, IHD, and EHD stones accounted for 76.3%, 24.3%, and 0.2% of all gallstone cases (concomitant cases were present). GB, IHD, and EHD gallstones presented different patterns by the age, gender, geographic and metabolic factors. Overall, the age-standardized prevalence was higher in women than that in men (5.41% vs. 4.85%, P<0.001). The gender standardized prevalence of all gallstone subtypes apparently increased with age (P<0.001), especially for GB stones from 1.05% (age 18-30) to 11.6% (age ≥70) (P<0.001). There was a marked geographic variation with AGS-prevalence ranging from 3.00% to 8.86% among different provinces. Noticeably, higher BMI, fasting glucose level, or total triglyceride level was associated with a higher prevalence of overall gallstones and GB stones (OR >1), but associated with a lower prevalence of IHD and EHD stones. Conclusions: The prevalence of gallstones in China largely varied in its anatomical location, demographic factors, geographic location, and metabolic factors, suggesting that the etiology of each subtype may be different. Further investigation should be conducted.
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