ArticleAnnals of translational medicine2022
Multimodal treatments of brain arteriovenous malformations: a comparison of microsurgical timings after endovascular embolization.
Article in Annals of translational medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03774017 (Study on Benefits and Risks of Hybrid Operation in the Treatment of Complex Brain Arteriovenous Malformations), which is not on this map. Cited by 7 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Study on Benefits and Risks of Hybrid Operation in the Treatment of Complex Brain Arteriovenous Malformations
Who cites it
7 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Optimal timing of microsurgical resection after preoperative embolization of intracranial arteriovenous malformations: A systematic review and meta-analysis of 1,469 patients.Neurosurgical review · 2026Pooled it
- Enhancing the quality of evidence, comparability, and reproducibility in brain arteriovenous malformations treated with open surgery research: a systematic review and proposal of a reporting guideline for surgical and clinical outcomes.Neurosurgical review · 2024Pooled it
- Review
- Emergency neurosurgical hybrid operating platform for acute intracranial hemorrhage (E-HOPE).Chinese neurosurgical journal · 2024Article
- Comparison of conservative management, microsurgery only, and microsurgery with preoperative embolization for unruptured arteriovenous malformations: A propensity score weighted prospective cohort study.CNS neuroscience & therapeutics · 2024Article
- Multi-Stage Treatment for Spetzler-Martin Grades III, IV, and V Arteriovenous Malformations: Preoperative Embolization and Microsurgical Resection in a Consecutive Series of 250 Patients.Journal of clinical medicine · 2023Article
- Is a single-staged endovascular embolization and microsurgical resection approach preferred to a multi-staged approach for the treatment of brain arteriovenous malformations?Annals of translational medicine · 2022Article
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11 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Background: To compare the clinical outcomes of hybrid microsurgery and embolization with multi-staged procedure for patients harboring brain arteriovenous malformations (bAVMs). Methods: We retrospectively reviewed bAVM patients from a multicenter, prospectively collected database (NCT03774017) between June 2016 and June 2020. Patients were divided into single-staged hybrid operation (HO) group and multi-staged operation (MO) group according to the received treatment, in which microsurgeries were performed with embolization in a single setting or with multi-stage procedure, respectively. Cases were 1:1 matched between the two groups. Outcomes were compared between groups, which included neurological deficits (NDs), perioperative rupture, and proportion of complete resection. Variables associated with NDs were analyzed. Results: In total, 198 out of 544 cases were identified, including 120 in the HO group and 78 in the MO group. Sixty-six cases were matched in each group resulting in a total of 132 patients in this case-controlled study. Mean age was 29.2 years old, with 82 (62.1%) being male. No significant difference was observed in baseline demographics and clinical characteristics between the two groups. There were 7 ruptures occurred in the interval between embolization and microsurgery for MO group while none in the HO group (P=0.023). This yielded a rupture risk of 4.1% per year for the MO group. Duration of surgical resection was significantly reduced in HO group (P=0.001). Compared to MO, HO was more favorable to avoid short-term NDs (3.0% Conclusions: HO is an effective setup to treat complex bAVMs with avoiding interval hemorrhage risk and reducing surgical risk. We also observed overall similar obliteration rate and resulting clinical outcomes between HO and MO.
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